4-IBP

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Cat.No. 0748 - 4-IBP | C19H21IN2O | CAS No. 155798-08-6
Description: σ ligand, σ1> σ2
Chemical Name: N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.

Technical Data

M. Wt 420.29
Formula C19H21IN2O
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 155798-08-6
PubChem ID 132995
InChI Key HELCSESNNDZLFM-UHFFFAOYSA-N
Smiles IC1=CC=C(C=C1)C(=O)NC1CCN(CC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mM in DMSO and to 5 mM in ethanol

References

References are publications that support the biological activity of the product.

Bermack and Debonnel (2001) Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 134 691 PMID: 11588125

John et al (1994) Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 37 1737 PMID: 8021913

Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571


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Keywords: 4-IBP, 4-IBP supplier, ligand, σ1, sigma1, σ2, sigma2, receptors, Sigma1, Receptors, 0748, Tocris Bioscience

2 Citations for 4-IBP

Citations are publications that use Tocris products. Selected citations for 4-IBP include:

Amer et al (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol 168 1445 PMID: 23121507

Rodríguez-Muñoz et al (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain 11 51 PMID: 30223868


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Literature in this Area

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