Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 10 mM in DMSO and to 5 mM in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 420.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.38 mL||11.9 mL||23.79 mL|
|5 mM||0.48 mL||2.38 mL||4.76 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Bermack and Debonnel (2001) Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 134 691 PMID: 11588125
John et al (1994) Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 37 1737 PMID: 8021913
Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571
If you know of a relevant reference for 4-IBP, please let us know.
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Keywords: 4-IBP, supplier, ligand, σ1, sigma1, σ2, sigma2, receptors, Sigma1, Receptors, Sigma1, Receptors, Tocris Bioscience
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