4-IBP

Pricing Availability Delivery Time Qty
Cat.No. 0748 - 4-IBP | C19H21IN2O | CAS No. 155798-08-6
Description: σ ligand, σ1> σ2
Chemical Name: N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.

Technical Data

M. Wt 420.29
Formula C19H21IN2O
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 155798-08-6
PubChem ID 132995
InChI Key HELCSESNNDZLFM-UHFFFAOYSA-N
Smiles IC1=CC=C(C=C1)C(=O)NC1CCN(CC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in DMSO and to 5 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 420.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.9 mL 23.79 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bermack and Debonnel (2001) Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 134 691 PMID: 11588125

John et al (1994) Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 37 1737 PMID: 8021913

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571


If you know of a relevant reference for 4-IBP, please let us know.

View Related Products by Target

View Related Products by Product Action

View all σ1 Receptor Ligands

Keywords: 4-IBP, supplier, ligand, σ1, sigma1, σ2, sigma2, receptors, Sigma1, Receptors, Tocris Bioscience

Citations for 4-IBP

Citations are publications that use Tocris products.

Currently there are no citations for 4-IBP. Do you know of a great paper that uses 4-IBP from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for 4-IBP

Protocols

TODO: Add Protocols