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Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 146.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.84 mL||34.21 mL||68.42 mL|
|5 mM||1.37 mL||6.84 mL||13.68 mL|
|10 mM||0.68 mL||3.42 mL||6.84 mL|
|50 mM||0.14 mL||0.68 mL||1.37 mL|
References are publications that support the biological activity of the product.
Banasik et al (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 267 1569 PMID: 1530940
Halmosi et al (2001) Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 59 1497 PMID: 11353811
Veres et al (2004) Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther. 310 247 PMID: 14999056
If you know of a relevant reference for 4-HQN, please let us know.
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Keywords: 4-HQN, 4-HQN supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, Poly(ADP-ribose), 2192, Tocris Bioscience
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.