Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 146.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.84 mL||34.21 mL||68.42 mL|
|5 mM||1.37 mL||6.84 mL||13.68 mL|
|10 mM||0.68 mL||3.42 mL||6.84 mL|
|50 mM||0.14 mL||0.68 mL||1.37 mL|
References are publications that support the products' biological activity.
Banasik et al (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 267 1569 PMID: 1530940
Halmosi et al (2001) Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 59 1497 PMID: 11353811
Veres et al (2004) Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther. 310 247 PMID: 14999056
If you know of a relevant reference for 4-HQN, please let us know.
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Keywords: 4-HQN, supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase, Tocris Bioscience
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