4-HQN

Discontinued Product

4-HQN (Cat. No. 2192) has been withdrawn from sale for commercial reasons.
Description: PARP inhibitor
Chemical Name: 4-(1H)-Quinazolinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for 4-HQN

Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.

Technical Data for 4-HQN

M. Wt 146.15
Formula C8H6N2O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 491-36-1
PubChem ID 63112
InChI Key QMNUDYFKZYBWQX-UHFFFAOYSA-N
Smiles OC1=C2C=CC=CC2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: 4-HQN, 4-HQN supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, Poly(ADP-ribose), 2192, Tocris Bioscience

Citations for 4-HQN

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Literature in this Area

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