4-Acetyl-1,1-dimethylpiperazinium iodide

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Cat.No. 0352 - 4-Acetyl-1,1-dimethylpiperazinium iodide | C8H17IN2O | CAS No. 75667-84-4
Description: nAChR agonist
Literature (3)

Biological Activity

Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.

Technical Data

M. Wt 284.14
Formula C8H17IN2O
Storage Store at RT
CAS Number 75667-84-4
PubChem ID 5311072
Smiles C[N+]1(C)CCN(CC1)C(=O)C.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 284.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.6 mL 35.19 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References are publications that support the biological activity of the product.

Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177 PMID: 2747625

Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127 PMID: 3485051

Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289

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Keywords: 4-Acetyl-1,1-dimethylpiperazinium iodide, 4-Acetyl-1,1-dimethylpiperazinium iodide supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetyldimethylpiperazinium, (Non-selective), 0352, Tocris Bioscience

Citations for 4-Acetyl-1,1-dimethylpiperazinium iodide

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Literature in this Area

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