4-Acetyl-1,1-dimethylpiperazinium iodide

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Cat.No. 0352 - 4-Acetyl-1,1-dimethylpiperazinium iodide | C8H17IN2O | CAS No. 75667-84-4
Description: Nicotinic agonist

Biological Activity

Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.

Technical Data

M. Wt 284.14
Formula C8H17IN2O
Storage Store at RT
CAS Number 75667-84-4
PubChem ID 5311072
Smiles C[N+]1(C)CCN(CC1)C(=O)C.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 284.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.6 mL 35.19 mL
5 mM 0.7 mL 3.52 mL 7.04 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177 PMID: 2747625

Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127 PMID: 3485051

Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289

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Citations for 4-Acetyl-1,1-dimethylpiperazinium iodide

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