Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 284.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.52 mL||17.6 mL||35.19 mL|
|5 mM||0.7 mL||3.52 mL||7.04 mL|
|10 mM||0.35 mL||1.76 mL||3.52 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177 PMID: 2747625
Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127 PMID: 3485051
Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289
If you know of a relevant reference for 4-Acetyl-1,1-dimethylpiperazinium iodide, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 4-Acetyl-1,1-dimethylpiperazinium iodide, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetyldimethylpiperazinium, Nicotinic, Receptors, (Non-selective), Tocris Bioscience
Citations for 4-Acetyl-1,1-dimethylpiperazinium iodide
Citations are publications that use Tocris products.
Currently there are no citations for 4-Acetyl-1,1-dimethylpiperazinium iodide. Do you know of a great paper that uses 4-Acetyl-1,1-dimethylpiperazinium iodide from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.