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Submit Review3-pyr-Cytisine
Discontinued Product
4125 has been discontinued.
Description: High affinity, partial agonist of α4β2 receptors
Chemical Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-9-(3-pyridinyl)-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥98% (HPLC)
Biological Activity for 3-pyr-Cytisine
High affinity α4β2 partial agonist (Ki values are 0.91, 119 and 1100 nM for α4β2, α3β4 and α7 receptors respectively). Shows little activity at α3β4 and α7 receptors. Exhibits antidepressant-like effects in mouse models of antidepressant efficacy.
Technical Data for 3-pyr-Cytisine
| M. Wt | 267.33 |
| Formula | C16H17N3O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 948027-43-8 |
| PubChem ID | 16731778 |
| InChI Key | GOYASQWDLRLAPK-WCQYABFASA-N |
| Smiles | O=C2N1C[C@@]([H])(C4)CNC[C@@]([H])4C1=CC=C2C3=CC=CN=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3-pyr-Cytisine
References for 3-pyr-Cytisine
References are publications that support the biological activity of the product.
Mineur et al (2009) Cytisine-based nicotinic partial agonists as novel antidepressant compounds. J.Pharmacol.Exp.Ther. 329 377 PMID: 19164465
Papke et al (2010) Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 333 501 PMID: 20100906
Papke et al (2011) Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists. J.Pharmacol.Exp.Ther. 337 1
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Keywords: 3-pyr-Cytisine, 3-pyr-Cytisine supplier, nicotinics, nachr, alpha4beta2, a4b2, α4β2, partial, agonists, Nicotinic, (a4b2), Receptors, 4125, Tocris Bioscience
Citations for 3-pyr-Cytisine
Citations are publications that use Tocris products.
Currently there are no citations for 3-pyr-Cytisine.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.