Pricing Availability Delivery Time Qty
Cat.No. 4125 - 3-pyr-Cytisine | C16H17N3O | CAS No. 948027-43-8
Description: High affinity, partial agonist of α4β2 receptors
Chemical Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-9-(3-pyridinyl)-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥98% (HPLC)

Biological Activity

High affinity α4β2 partial agonist (Ki values are 0.91, 119 and 1100 nM for α4β2, α3β4 and α7 receptors respectively). Shows little activity at α3β4 and α7 receptors. Exhibits antidepressant-like effects in mouse models of antidepressant efficacy.

Technical Data

M. Wt 267.33
Formula C16H17N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 948027-43-8
PubChem ID 16731778
Smiles O=C2N1C[C@@]([H])(C4)CNC[C@@]([H])4C1=CC=C2C3=CC=CN=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.73 100
water 26.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.7 mL 37.41 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References are publications that support the products' biological activity.

Mineur et al (2009) Cytisine-based nicotinic partial agonists as novel antidepressant compounds. J.Pharmacol.Exp.Ther. 329 377 PMID: 19164465

Papke et al (2010) Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 333 501 PMID: 20100906

Papke et al (2011) Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists. J.Pharmacol.Exp.Ther. 337 1 PMID:

If you know of a relevant reference for 3-pyr-Cytisine, please let us know.

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Pathways for 3-pyr-Cytisine


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