27-Hydroxycholesterol

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Cat.No. 3907 - 27-Hydroxycholesterol | C27H46O2 | CAS No. 20380-11-4
Description: LXR agonist; also ER partial agonist
Alternative Names: 27 OHC, 27 HC
Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

Technical Data

M. Wt 402.65
Formula C27H46O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 20380-11-4
PubChem ID 123976
InChI Key FYHRJWMENCALJY-YSQMORBQSA-N
Smiles O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC[C@@H](C)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 8.05 20

Preparing Stock Solutions

The following data is based on the product molecular weight 402.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.84 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rantham Prabhakara et al (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem. 107 1722 PMID: 19014385

Fu et al (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem. 276 38378 PMID: 11504730

DuSell et al (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol. 22 65 PMID: 17872378


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Citations for 27-Hydroxycholesterol

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Literature in this Area

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Pathways for 27-Hydroxycholesterol

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