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Description: LXR agonist; also ER partial agonist
Alternative Names: 27 OHC,27 HC
Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Purity: ≥95% (HPLC)
Citations (2)

Biological Activity for 27-Hydroxycholesterol

27-Hydroxycholesterol is a liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

Technical Data for 27-Hydroxycholesterol

M. Wt 402.65
Formula C27H46O2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 20380-11-4
PubChem ID 123976
Smiles O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC[C@@H](C)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 27-Hydroxycholesterol

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 8.05 20

Preparing Stock Solutions for 27-Hydroxycholesterol

The following data is based on the product molecular weight 402.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.42 mL 62.09 mL 124.18 mL
1 mM 2.48 mL 12.42 mL 24.84 mL
2 mM 1.24 mL 6.21 mL 12.42 mL
10 mM 0.25 mL 1.24 mL 2.48 mL

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Product Datasheets for 27-Hydroxycholesterol

Certificate of Analysis / Product Datasheet
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References for 27-Hydroxycholesterol

References are publications that support the biological activity of the product.

Rantham Prabhakara et al (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem. 107 1722 PMID: 19014385

Fu et al (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem. 276 38378 PMID: 11504730

DuSell et al (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol. 22 65 PMID: 17872378

If you know of a relevant reference for 27-Hydroxycholesterol, please let us know.

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Keywords: 27-Hydroxycholesterol, 27-Hydroxycholesterol supplier, 27OHC, 27HC, liver-x, receptors, agonists, estrogen, partial, SERM, selective, modulators, cholesterol, 27, OHC, HC, LXR-like, Receptors, Estrogen, and, Related, 3907, Tocris Bioscience

2 Citations for 27-Hydroxycholesterol

Citations are publications that use Tocris products. Selected citations for 27-Hydroxycholesterol include:

Gibson et al (2018) The impact of 27-hydroxycholesterol on endometrial cancer proliferation. Endocr Relat Cancer 25 381 PMID: 29371332

Schommer et al (2018) 27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons. BMC Neurosci 19 17 PMID: 29614969

Do you know of a great paper that uses 27-Hydroxycholesterol from Tocris? Please let us know.

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