2-TEDC

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Cat.No. 0645 - 2-TEDC | C16H13NO4S | CAS No. 132465-10-2
Description: 5-, 12-, 15-Lipoxygenase inhibitor
Chemical Name: 2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC50 values are 0.09, 0.013 and 0.5 μM respectively).

Technical Data

M. Wt 315.34
Formula C16H13NO4S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 132465-10-2
PubChem ID 6069552
InChI Key KCGLTUBCAGZLHP-XYOKQWHBSA-N
Smiles OC1=C(O)C=C(\C=C(/C#N)C(=O)OCCC2=CC=CS2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 25 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 315.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cho et al (1991) Novel caffeic acid derivatives - extremely potent inhibitors of 12-lipoxygenase. J.Med.Chem. 34 1503 PMID: 2016727


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Keywords: 2-TEDC, supplier, 5-lipoxygenase, 12-lipoxygenase, 15-Lipoxygenase, inhibitors, inhibits, Oxygenases, Oxidases, 5-LOX, 12-LOX, 15-LOX, Lipoxygenase, Tocris Bioscience

Citations for 2-TEDC

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Literature in this Area

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Pathways for 2-TEDC

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