Pricing Availability   Qty
Description: 5-, 12-, 15-Lipoxygenase inhibitor
Chemical Name: 2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate
Purity: ≥99% (HPLC)

Biological Activity for 2-TEDC

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC50 values are 0.09, 0.013 and 0.5 μM respectively).

Technical Data for 2-TEDC

M. Wt 315.34
Formula C16H13NO4S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 132465-10-2
PubChem ID 6069552
Smiles OC1=C(O)C=C(\C=C(/C#N)C(=O)OCCC2=CC=CS2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-TEDC

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 100
ethanol 25

Preparing Stock Solutions for 2-TEDC

The following data is based on the product molecular weight 315.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for 2-TEDC

References are publications that support the biological activity of the product.

Cho et al (1991) Novel caffeic acid derivatives - extremely potent inhibitors of 12-lipoxygenase. J.Med.Chem. 34 1503 PMID: 2016727

If you know of a relevant reference for 2-TEDC, please let us know.

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Keywords: 2-TEDC, 2-TEDC supplier, 5-lipoxygenase, 12-lipoxygenase, 15-Lipoxygenase, inhibitors, inhibits, Oxygenases, Oxidases, 5-LOX, 12-LOX, 15-LOX, Lipoxygenase, 0645, Tocris Bioscience

Citations for 2-TEDC

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