2-Pyridylethylamine dihydrochloride

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Description: H1 agonist
Chemical Name: 2-Pyridineethanamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity for 2-Pyridylethylamine dihydrochloride

2-Pyridylethylamine dihydrochloride is a histamine H1 receptor agonist that produces vasoconstriction in vivo.

Compound Libraries for 2-Pyridylethylamine dihydrochloride

2-Pyridylethylamine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 2-Pyridylethylamine dihydrochloride

M. Wt 195.09
Formula C7H10N2.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 3343-39-3
PubChem ID 201148
InChI Key GPIFKSYYILNJNR-UHFFFAOYSA-N
Smiles Cl.Cl.NCCC1=NC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-Pyridylethylamine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.51 100
DMSO 9.75 50

Preparing Stock Solutions for 2-Pyridylethylamine dihydrochloride

The following data is based on the product molecular weight 195.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.13 mL 25.63 mL 51.26 mL
5 mM 1.03 mL 5.13 mL 10.25 mL
10 mM 0.51 mL 2.56 mL 5.13 mL
50 mM 0.1 mL 0.51 mL 1.03 mL

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Product Datasheets for 2-Pyridylethylamine dihydrochloride

Certificate of Analysis / Product Datasheet
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References for 2-Pyridylethylamine dihydrochloride

References are publications that support the biological activity of the product.

Martinez-Mir et al (1992) Effect of histamine and histamine analogues on human isolated myometrial strips. Br.J.Pharmacol. 107 528 PMID: 1358393

Arai and Chiba (1999) Endothelium-dependent vasodilation mechanisms by histamine in simian but not in canine femoral arterial branches. J.Auton.Pharmacol. 19 267 PMID: 10759332


If you know of a relevant reference for 2-Pyridylethylamine dihydrochloride, please let us know.

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Keywords: 2-Pyridylethylamine dihydrochloride, 2-Pyridylethylamine dihydrochloride supplier, H1, receptor, agonists, Receptors, Histamine, histaminergic, 2478, Tocris Bioscience

2 Citations for 2-Pyridylethylamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for 2-Pyridylethylamine dihydrochloride include:

Jain et al (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315 E357 PMID: 29812984

Ashina et al (2015) Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo. Mol Med Rep 10 e0132367 PMID: 26158531


Do you know of a great paper that uses 2-Pyridylethylamine dihydrochloride from Tocris? Please let us know.

Reviews for 2-Pyridylethylamine dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

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Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.