2-PMDQ

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Cat.No. 0627 - 2-PMDQ | C21H23N5O | CAS No. 139047-55-5
Description: Potent, selective α1 antagonist
Chemical Name: 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
Datasheet
Citations
Literature

Biological Activity

Potent and selective α1-adrenoceptor antagonist and antihypertensive.

Technical Data

M. Wt 361.45
Formula C21H23N5O
Storage Store at RT
CAS Number 139047-55-5
PubChem ID 6081682
InChI Key ONSOQRPYFKDOEB-UHFFFAOYSA-N
Smiles O=C1NC2=C(C=CC=C2)C2=NC(CN3CCN(CC3)C3=CC=CC=C3)CN12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.61 10
ethanol 0

Preparing Stock Solutions

The following data is based on the product molecular weight 361.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Chern et al (1993) Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives - a novel class of potent and selective α1-adrenoceptor antagonists and antihypertensive agents. J.Med.Chem. 36 2196 PMID: 8101878


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