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Cat.No. 5033 - 2-MPPA | C8H14O4S | CAS No. 254737-29-6
Description: Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
Chemical Name: 2-(3-Mercaptopropyl)pentanedioic acid

Biological Activity for 2-MPPA

2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.

Technical Data for 2-MPPA

M. Wt 206.26
Formula C8H14O4S
Storage Store at -20°C
CAS Number 254737-29-6
PubChem ID 10198171
Smiles SCCCC(C(O)=O)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-MPPA

Solvent Max Conc. mg/mL Max Conc. mM
water 20.63 100
DMSO 20.63 100

Preparing Stock Solutions for 2-MPPA

The following data is based on the product molecular weight 206.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.85 mL 24.24 mL 48.48 mL
5 mM 0.97 mL 4.85 mL 9.7 mL
10 mM 0.48 mL 2.42 mL 4.85 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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References for 2-MPPA

References are publications that support the biological activity of the product.

Majer et al (2003) Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J.Med.Chem. 46 1989 PMID: 12723961

Ghadge et al (2003) Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc.Natl.Acad.Sci.U.S.A. 100 9554 PMID: 12876198

Vornov et al (2013) Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism. J.Pharmacol.Exp.Ther. 346 406 PMID: 23776202

If you know of a relevant reference for 2-MPPA, please let us know.

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Citations for 2-MPPA

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