Selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 206.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.85 mL||24.24 mL||48.48 mL|
|5 mM||0.97 mL||4.85 mL||9.7 mL|
|10 mM||0.48 mL||2.42 mL||4.85 mL|
|50 mM||0.1 mL||0.48 mL||0.97 mL|
References are publications that support the biological activity of the product.
Majer et al (2003) Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J.Med.Chem. 46 1989 PMID: 12723961
Ghadge et al (2003) Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc.Natl.Acad.Sci.U.S.A. 100 9554 PMID: 12876198
Vornov et al (2013) Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism. J.Pharmacol.Exp.Ther. 346 406 PMID: 23776202
If you know of a relevant reference for 2-MPPA, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 2-MPPA, 2-MPPA supplier, selective, glutamate, carboxypeptidase, 2, II, GCP2, GCPII, inhibitors, inhibits, neuroprotective, antinociceptive, orally, bioavailable, Carboxypeptidase, Miscellaneous, Glutamate, 5033, Tocris Bioscience
Citations for 2-MPPA
Citations are publications that use Tocris products.
Currently there are no citations for 2-MPPA. Do you know of a great paper that uses 2-MPPA from Tocris? Please let us know.
Reviews for 2-MPPA
There are currently no reviews for this product. Be the first to review 2-MPPA and earn rewards!
Have you used 2-MPPA?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)New
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells