Discontinued Product

2-MPPA (Cat. No. 5033) has been withdrawn from sale for commercial reasons.
Cat.No. 5033 - 2-MPPA | C8H14O4S | CAS No. 254737-29-6
Description: Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
Chemical Name: 2-(3-Mercaptopropyl)pentanedioic acid

Biological Activity for 2-MPPA

2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.

Technical Data for 2-MPPA

M. Wt 206.26
Formula C8H14O4S
Storage Store at -20°C
CAS Number 254737-29-6
PubChem ID 10198171
Smiles SCCCC(C(O)=O)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: 2-MPPA, 2-MPPA supplier, selective, glutamate, carboxypeptidase, 2, II, GCP2, GCPII, inhibitors, inhibits, neuroprotective, antinociceptive, orally, bioavailable, Carboxypeptidase, Miscellaneous, Glutamate, 5033, Tocris Bioscience

Citations for 2-MPPA

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