Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review2-MPPA
Description: Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
Chemical Name: 2-(3-Mercaptopropyl)pentanedioic acid
Biological Activity for 2-MPPA
2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.
Technical Data for 2-MPPA
| M. Wt | 206.26 |
| Formula | C8H14O4S |
| Storage | Store at -20°C |
| CAS Number | 254737-29-6 |
| PubChem ID | 10198171 |
| InChI Key | FNLNSQHJKVQCBP-UHFFFAOYSA-N |
| Smiles | SCCCC(C(O)=O)CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-MPPA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.63 | 100 | |
| DMSO | 20.63 | 100 |
Preparing Stock Solutions for 2-MPPA
The following data is based on the product molecular weight 206.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.85 mL | 24.24 mL | 48.48 mL |
| 5 mM | 0.97 mL | 4.85 mL | 9.7 mL |
| 10 mM | 0.48 mL | 2.42 mL | 4.85 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.97 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for 2-MPPA
References for 2-MPPA
References are publications that support the biological activity of the product.
Majer et al (2003) Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J.Med.Chem. 46 1989 PMID: 12723961
Ghadge et al (2003) Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc.Natl.Acad.Sci.U.S.A. 100 9554 PMID: 12876198
Vornov et al (2013) Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism. J.Pharmacol.Exp.Ther. 346 406 PMID: 23776202
If you know of a relevant reference for 2-MPPA, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 2-MPPA, 2-MPPA supplier, selective, glutamate, carboxypeptidase, 2, II, GCP2, GCPII, inhibitors, inhibits, neuroprotective, antinociceptive, orally, bioavailable, Carboxypeptidase, Miscellaneous, Glutamate, 5033, Tocris Bioscience
Citations for 2-MPPA
Citations are publications that use Tocris products.
Currently there are no citations for 2-MPPA. Do you know of a great paper that uses 2-MPPA from Tocris? Please let us know.
Reviews for 2-MPPA
There are currently no reviews for this product. Be the first to review 2-MPPA and earn rewards!
Have you used 2-MPPA?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image