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Cat.No. 0661 - 2-MPMDQ | C23H27N5O2 | CAS No. 149847-77-8
Description: Potent, selective α1 antagonist. Also σ2 ligand
Chemical Name: 2-[[4-(2-Methoxyphenyl)piperazin-1-yl]methyl-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one
Literature (4)

Biological Activity

Potent and selective α1-adrenoceptor antagonist; hypotensive.

Technical Data

M. Wt 405.5
Formula C23H27N5O2
Storage Store at RT
CAS Number 149847-77-8
PubChem ID 4534085
Smiles COC1=C(C=CC=C1)N1CCN(CC2CN3C(=N2)C2=CC=CC=C2N(C)C3=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.27 50

Preparing Stock Solutions

The following data is based on the product molecular weight 405.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.93 mL 24.66 mL 49.32 mL
2.5 mM 0.99 mL 4.93 mL 9.86 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
25 mM 0.1 mL 0.49 mL 0.99 mL

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Product Datasheets

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References are publications that support the biological activity of the product.

Chern et al (1993) Studies on quinazolines. 2,3-Dihydroimidazo[1,2c]quinazoline derivatives. A novel class of potent and selective α1-adrenoceptor antagonists and antihypertensive agents. J.Med.Chem. 36 2196 PMID: 8101878

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