2-MPMDQ

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Cat.No. 0661 - 2-MPMDQ | C23H27N5O2 | CAS No. 149847-77-8
Description: Potent, selective α1 antagonist. Also σ2 ligand
Chemical Name: 2-[[4-(2-Methoxyphenyl)piperazin-1-yl]methyl-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one
Datasheet
Citations
Literature

Biological Activity

Potent and selective α1-adrenoceptor antagonist; hypotensive.

Technical Data

M. Wt 405.5
Formula C23H27N5O2
Storage Store at RT
CAS Number 149847-77-8
PubChem ID 4534085
InChI Key OULFYKAESNCMFJ-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C1)N1CCN(CC2CN3C(=N2)C2=CC=CC=C2N(C)C3=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.27 50

Preparing Stock Solutions

The following data is based on the product molecular weight 405.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.33 mL 24.66 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Chern et al (1993) Studies on quinazolines. 2,3-Dihydroimidazo[1,2c]quinazoline derivatives. A novel class of potent and selective α1-adrenoceptor antagonists and antihypertensive agents. J.Med.Chem. 36 2196 PMID: 8101878


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Literature in this Area

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Pathways for 2-MPMDQ

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