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Description: Potent, selective α1 antagonist. Also σ2 ligand
Chemical Name: 2-[[4-(2-Methoxyphenyl)piperazin-1-yl]methyl-6-methyl-2,3-dihydroimidazo[1,2c]quinazolin-5(6H)-one
Biological Activity
Potent and selective α1-adrenoceptor antagonist; hypotensive.
Technical Data
| M. Wt | 405.5 |
| Formula | C23H27N5O2 |
| Storage | Store at RT |
| CAS Number | 149847-77-8 |
| PubChem ID | 4534085 |
| InChI Key | OULFYKAESNCMFJ-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC=C1)N1CCN(CC2CN3C(=N2)C2=CC=CC=C2N(C)C3=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.27 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 405.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.93 mL | 24.66 mL | 49.32 mL |
| 2.5 mM | 0.99 mL | 4.93 mL | 9.86 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
| 25 mM | 0.1 mL | 0.49 mL | 0.99 mL |
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Product Datasheets
Certificate of Analysis is currently unavailable on-line.
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References
References are publications that support the biological activity of the product.
Chern et al (1993) Studies on quinazolines. 2,3-Dihydroimidazo[1,2c]quinazoline derivatives. A novel class of potent and selective α1-adrenoceptor antagonists and antihypertensive agents. J.Med.Chem. 36 2196 PMID: 8101878
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Literature in this Area
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