2-Methyl-5-hydroxytryptamine hydrochloride

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Cat.No. 0558 - 2-Methyl-5-hydroxytryptamine hydrochloride | C11H14N2O.HCl | CAS No. 845861-49-6
Description: 5-HT3 agonist/potent 5-HT6 ligand
Purity: ≥98% (HPLC)

Biological Activity

5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).

Technical Data

M. Wt 226.71
Formula C11H14N2O.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 845861-49-6
PubChem ID 11492320
Smiles Cl.CC1=C(CCN)C2=CC(O)=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 22.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 226.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.41 mL 22.05 mL 44.11 mL
5 mM 0.88 mL 4.41 mL 8.82 mL
10 mM 0.44 mL 2.21 mL 4.41 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9 PMID: 2402303

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164

Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755 PMID: 2299641

Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974

If you know of a relevant reference for 2-Methyl-5-hydroxytryptamine hydrochloride, please let us know.

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.