2-Methyl-5-hydroxytryptamine hydrochloride

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Cat.No. 0558 - 2-Methyl-5-hydroxytryptamine hydrochloride | C11H14N2O.HCl | CAS No. 845861-49-6
Description: 5-HT3 agonist/potent 5-HT6 ligand
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).

Technical Data

M. Wt 226.71
Formula C11H14N2O.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 845861-49-6
PubChem ID 11492320
InChI Key ZNVRHQPXSBWLQP-UHFFFAOYSA-N
Smiles Cl.CC1=C(CCN)C2=CC(O)=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 226.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.41 mL 22.05 mL 44.11 mL
5 mM 0.88 mL 4.41 mL 8.82 mL
10 mM 0.44 mL 2.21 mL 4.41 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9 PMID: 2402303

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164

Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755 PMID: 2299641

Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974


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Keywords: 2-Methyl-5-hydroxytryptamine hydrochloride, 2-Methyl-5-hydroxytryptamine hydrochloride supplier, 5-HT3, agonists, potent, 5-HT6, ligand, Serotonin, Receptors, 2-Me-5HT, 2, methyl5HT, 0558, Tocris Bioscience

Citations for 2-Methyl-5-hydroxytryptamine hydrochloride

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Literature in this Area

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Ion Channel

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.