Discontinued Product

2-Methoxyestradiol (Cat. No. 1807) has been withdrawn from sale for commercial reasons.
Description: Apoptotic and antiangiogenic agent
Chemical Name: (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)
Pathways (1)

Biological Activity for 2-Methoxyestradiol

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Technical Data for 2-Methoxyestradiol

M. Wt 302.41
Formula C19H26O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 362-07-2
PubChem ID 66414
Smiles OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 2-Methoxyestradiol

References for 2-Methoxyestradiol

References are publications that support the biological activity of the product.

D'Amato et al (1994) 2-MethoxyOE, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colch. site. Proc.Natl.Acad.Sci.U.S.A. 91 3964 PMID: 8171020

LaVallee et al (2002) 2-MethoxyOE inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 62 3691 PMID: 12097276

LaVallee et al (2003) 2-MethoxyOE up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63 468 PMID: 12543804

Shimada et al (2003) Roles of p38 and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyOE-induced p53 induction and apoptosis. Carcinogenesis 24 1067 PMID: 12807754

Keywords: 2-Methoxyestradiol, 2-Methoxyestradiol supplier, Apoptotic, agent, Apoptosis, Inducer, Antiangiogenics, Inducers, 1807, Tocris Bioscience

1 Citation for 2-Methoxyestradiol

Citations are publications that use Tocris products. Selected citations for 2-Methoxyestradiol include:

Valencia-Cervantes et al (2019) Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia-inducible factor 1α-mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. Oncol Rep 41 178 PMID: 30320358

Reviews for 2-Methoxyestradiol

There are currently no reviews for this product. Be the first to review 2-Methoxyestradiol and earn rewards!

Have you used 2-Methoxyestradiol?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for 2-Methoxyestradiol

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.