2-CMDO

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Cat.No. 0782 - 2-CMDO | C19H19ClN2O.C4H4O4 | CAS No. 24140-98-5
Description: D2-like antagonist. Displays some D4 selectivity
Chemical Name: 2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate
Datasheet
Citations
Literature

Biological Activity

Dopamine D2-like receptor antagonist that displays some selectivity for D4 receptors (Ki values are 0.54 and 2.5 nM for D4 and D2 receptors respectively).

Technical Data

M. Wt 442.9
Formula C19H19ClN2O.C4H4O4
Storage Store at RT
CAS Number 24140-98-5
PubChem ID 71296946
InChI Key OOHVXDUNWCMZCI-WLHGVMLRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CN1CCN(CC1)C1=CC2=C(OC3=C1C=C(Cl)C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.29 100

Preparing Stock Solutions

The following data is based on the product molecular weight 442.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.29 mL 22.58 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Phillips et al (1994) Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of clozapine to dopamine and serotonin receptors. J.Med.Chem. 37 2686 PMID: 8064797

Phillips et al (1995) Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of clozapine to dopamine and serotonin receptors. J.Med.Chem. 38 708 PMID: 7861418

Zawilska et al (2003) L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors. J.Neural Transm. 110 219 PMID: 12658371


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Keywords: 2-CMDO, supplier, D2-like, antagonists, Displays, D4, selectivity, Dopamine, Non-Selective, Receptors, dopaminergic, 2-Chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin, maleate, Non-selective, Dopamine, Tocris Bioscience

Citations for 2-CMDO

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Pathways for 2-CMDO

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