Discontinued Product

2-CMDO (Cat. No. 0782) has been withdrawn from sale for commercial reasons.
Cat.No. 0782 - 2-CMDO | C19H19ClN2O.C4H4O4 | CAS No. 24140-98-5
Description: D2-like antagonist; displays some D4 selectivity
Chemical Name: 2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate
Literature (5)

Biological Activity for 2-CMDO

2-CMDO is a dopamine D2-like receptor antagonist that displays some selectivity for D4 receptors (Ki values are 0.54 and 2.5 nM for D4 and D2 receptors respectively).

Technical Data for 2-CMDO

M. Wt 442.9
Formula C19H19ClN2O.C4H4O4
Storage Store at RT
CAS Number 24140-98-5
PubChem ID 71296946
Smiles [H]OC(=O)\C=C\C(=O)O[H].CN1CCN(CC1)C1=CC2=C(OC3=C1C=C(Cl)C=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for 2-CMDO

References are publications that support the biological activity of the product.

Phillips et al (1994) Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 37 2686 PMID: 8064797

Phillips et al (1995) Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 38 708 PMID: 7861418

Zawilska et al (2003) L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-DA receptors. J.Neural Transm. 110 219 PMID: 12658371

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Keywords: 2-CMDO, 2-CMDO supplier, D2-like, antagonists, Displays, D4, selectivity, Dopamine, Non-Selective, Receptors, dopaminergic, 2-Chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin, maleate, Non-selective, 0782, Tocris Bioscience

Citations for 2-CMDO

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Currently there are no citations for 2-CMDO.

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