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A potent inhibitor of iNOS derived from mouse RAW 264.7 cells (IC50 = 6 nM), although less potent on human recombinant NOS isozymes with IC50 values of 100, 40 and 90 nM at nNOS, iNOS and eNOS respectively. Active in vivo, it shows 6.9-fold selectivity for iNOS vs. eNOS in conscious rats.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Faraci et al (1996) 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br.J.Pharmacol. 119 1101 PMID: 8937711
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999
Merck Index 12 486
Keywords: 2-Amino-4-methylpyridine, 2-Amino-4-methylpyridine supplier, iNOS, 1020, Tocris Bioscience
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