Discontinued Product2-Amino-4-methylpyridine (Cat. No. 1020) has been withdrawn from sale for commercial reasons.
A potent inhibitor of iNOS derived from mouse RAW 264.7 cells (IC50 = 6 nM), although less potent on human recombinant NOS isozymes with IC50 values of 100, 40 and 90 nM at nNOS, iNOS and eNOS respectively. Active in vivo, it shows 6.9-fold selectivity for iNOS vs. eNOS in conscious rats.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Faraci et al (1996) 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br.J.Pharmacol. 119 1101 PMID: 8937711
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999
Merck Index 12 486
View Related Products by Product Action
Keywords: 2-Amino-4-methylpyridine, 2-Amino-4-methylpyridine supplier, iNOS, 1020, Tocris Bioscience
Citations for 2-Amino-4-methylpyridine
Citations are publications that use Tocris products.
Currently there are no citations for 2-Amino-4-methylpyridine.
Reviews for 2-Amino-4-methylpyridine
There are currently no reviews for this product. Be the first to review 2-Amino-4-methylpyridine and earn rewards!
Have you used 2-Amino-4-methylpyridine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.