2-Amino-4-methylpyridine

Discontinued Product

Unfortunately 2-Amino-4-methylpyridine (Cat. No. 1020) has been withdrawn from sale for commercial reasons.
Cat.No. 1020 - 2-Amino-4-methylpyridine | CAS No. 695-34-1
Description: iNOS inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

A potent inhibitor of iNOS derived from mouse RAW 264.7 cells (IC50 = 6 nM), although less potent on human recombinant NOS isozymes with IC50 values of 100, 40 and 90 nM at nNOS, iNOS and eNOS respectively. Active in vivo, it shows 6.9-fold selectivity for iNOS vs. eNOS in conscious rats.

Technical Data

M. Wt 108.14
Storage Store at RT
CAS Number 695-34-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 108.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.25 mL 46.24 mL 92.47 mL
5 mM 1.85 mL 9.25 mL 18.49 mL
10 mM 0.92 mL 4.62 mL 9.25 mL
50 mM 0.18 mL 0.92 mL 1.85 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Faraci et al (1996) 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br.J.Pharmacol. 119 1101 PMID: 8937711

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999

Merck Index 12 486 PMID:

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Keywords: 2-Amino-4-methylpyridine, supplier, iNOS, iNOS, Tocris Bioscience

Citations for 2-Amino-4-methylpyridine

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Currently there are no citations for 2-Amino-4-methylpyridine.

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Literature in this Area

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