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5-HT4 receptor agonist with moderate activity as a 5-HT3 antagonist. Has no affinity at 5-HT1 or dopamine D2 receptors. Potential gastrokinetic agent.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.53||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 353.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||28.29 mL||141.47 mL||282.93 mL|
|0.5 mM||5.66 mL||28.29 mL||56.59 mL|
|1 mM||2.83 mL||14.15 mL||28.29 mL|
|5 mM||0.57 mL||2.83 mL||5.66 mL|
References are publications that support the biological activity of the product.
Monge et al (1994) Synthesis of 2-piperazinybenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J.Med.Chem. 37 1320 PMID: 8176710
If you know of a relevant reference for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole, please let us know.
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Keywords: 2-[1-(4-Piperonyl)piperazinyl]benzothiazole, 2-[1-(4-Piperonyl)piperazinyl]benzothiazole supplier, 5-HT4, agonists, 5-HT3, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 0736, Tocris Bioscience
1 Citation for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole
Citations are publications that use Tocris products. Selected citations for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole include:
Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621
Do you know of a great paper that uses 2-[1-(4-Piperonyl)piperazinyl]benzothiazole from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.