2-[1-(4-Piperonyl)piperazinyl]benzothiazole

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Cat.No. 0736 - 2-[1-(4-Piperonyl)piperazinyl]benzothiazole | C19H19N3O2S | CAS No. 155106-73-3
Description: 5-HT4 agonist. Also 5-HT3 antagonist
Datasheet
Citations (1)
Literature

Biological Activity

5-HT4 receptor agonist with moderate activity as a 5-HT3 antagonist. Has no affinity at 5-HT1 or dopamine D2 receptors. Potential gastrokinetic agent.

Technical Data

M. Wt 353.44
Formula C19H19N3O2S
Storage Store at RT
CAS Number 155106-73-3
PubChem ID 127902
InChI Key BYHKGNWKJMGHGE-UHFFFAOYSA-N
Smiles C(N1CCN(CC1)C1=NC2=CC=CC=C2S1)C1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.53 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 353.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.29 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Monge et al (1994) Synthesis of 2-piperazinybenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J.Med.Chem. 37 1320 PMID: 8176710


If you know of a relevant reference for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole, please let us know.

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1 Citation for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole

Citations are publications that use Tocris products. Selected citations for 2-[1-(4-Piperonyl)piperazinyl]benzothiazole include:

Gill et al (2008) Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 295 G700 PMID: 18669621


Do you know of a great paper that uses 2-[1-(4-Piperonyl)piperazinyl]benzothiazole from Tocris? If so please let us know.

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