16673-34-0 NLRP3i

Pricing Availability   Qty
Cat.No. 6774 - 16673-34-0 NLRP3i | C16H17ClN2O4S | CAS No. 16673-34-0
Description: NLRP3 inflammasome inhibitor
Chemical Name: N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.

Technical Data

M. Wt 368.84
Formula C16H17ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 16673-34-0
PubChem ID 85542
InChI Key KVWWTCSJLGHLRM-UHFFFAOYSA-N
Smiles COC1=C(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)C=C(C=C1)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.44 50

Preparing Stock Solutions

The following data is based on the product molecular weight 368.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.42 mL 27.11 mL 54.22 mL
2.5 mM 1.08 mL 5.42 mL 10.84 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID: 24336017


If you know of a relevant reference for 16673-34-0 NLRP3i, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Inflammasomes Inhibitors

Keywords: 16673-34-0 NLRP3i, 16673-34-0 NLRP3i supplier, NLRP3, inflammasome, inhibitors, inhibits, ischemia, reperfusion, injury, glyburide, impurity, intermediate, acute, myocardial, infarction, AMI, Inflammasomes, 6774, Tocris Bioscience

Citations for 16673-34-0 NLRP3i

Citations are publications that use Tocris products.

Currently there are no citations for 16673-34-0 NLRP3i. Do you know of a great paper that uses 16673-34-0 NLRP3i from Tocris? Please let us know.

Reviews for 16673-34-0 NLRP3i

There are currently no reviews for this product. Be the first to review 16673-34-0 NLRP3i and earn rewards!

Have you used 16673-34-0 NLRP3i?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling