You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 368.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.42 mL||27.11 mL||54.22 mL|
|2.5 mM||1.08 mL||5.42 mL||10.84 mL|
|5 mM||0.54 mL||2.71 mL||5.42 mL|
|25 mM||0.11 mL||0.54 mL||1.08 mL|
References are publications that support the biological activity of the product.
Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID: 24336017
Fulp et al (2018) Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 61 5412
If you know of a relevant reference for 16673-34-0 NLRP3i, please let us know.
View Related Products by Product Action
Keywords: 16673-34-0 NLRP3i, 16673-34-0 NLRP3i supplier, NLRP3, inflammasome, inhibitors, inhibits, ischemia, reperfusion, injury, glyburide, impurity, intermediate, acute, myocardial, infarction, AMI, JC121, Inflammasomes, 6774, Tocris Bioscience
Citations for 16673-34-0 NLRP3i
Citations are publications that use Tocris products.
Currently there are no citations for 16673-34-0 NLRP3i. Do you know of a great paper that uses 16673-34-0 NLRP3i from Tocris? Please let us know.
Reviews for 16673-34-0 NLRP3i
There are currently no reviews for this product. Be the first to review 16673-34-0 NLRP3i and earn rewards!
Have you used 16673-34-0 NLRP3i?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.