1-Methylpsilocin

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Cat.No. 3017 - 1-Methylpsilocin | C13H18N2O | CAS No. 1465-16-3
Description: Potent and selective 5-HT2C agonist
Chemical Name: 3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.

Technical Data

M. Wt 218.29
Formula C13H18N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1465-16-3
PubChem ID 44404883
InChI Key MZZRFEIDRWKTKJ-UHFFFAOYSA-N
Smiles OC1=C2C(N(C)C=C2CCN(C)C)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.83 100
ethanol 2.18 10

Preparing Stock Solutions

The following data is based on the product molecular weight 218.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.81 mL
5 mM 0.92 mL 4.58 mL 9.16 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sard et al (2005) SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist. Bioorg.Med.Chem.Letts. 15 4559 PMID:


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Keywords: Potent selective 5-HT2C agonists Serotonin Receptors 5-HT2C Receptors

Citations for 1-Methylpsilocin

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Literature in this Area

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Pathways for 1-Methylpsilocin

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