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Description: Potent and selective 5-HT2C agonist
Chemical Name: 3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity for 1-Methylpsilocin

1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.

Technical Data for 1-Methylpsilocin

M. Wt 218.29
Formula C13H18N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1465-16-3
PubChem ID 44404883
Smiles OC1=C2C(N(C)C=C2CCN(C)C)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Methylpsilocin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.83 100
ethanol 2.18 10

Preparing Stock Solutions for 1-Methylpsilocin

The following data is based on the product molecular weight 218.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.81 mL
5 mM 0.92 mL 4.58 mL 9.16 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets for 1-Methylpsilocin

Certificate of Analysis / Product Datasheet
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References for 1-Methylpsilocin

References are publications that support the biological activity of the product.

Sard et al (2005) SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist. Bioorg.Med.Chem.Letts. 15 4559

If you know of a relevant reference for 1-Methylpsilocin, please let us know.

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Keywords: 1-Methylpsilocin, 1-Methylpsilocin supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, 3017, Tocris Bioscience

1 Citation for 1-Methylpsilocin

Citations are publications that use Tocris products. Selected citations for 1-Methylpsilocin include:

Halberstadt et al (2011) Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J.Psychopharmacol. 25 1548 PMID: 21148021

Do you know of a great paper that uses 1-Methylpsilocin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.