1-Methyl-D-tryptophan

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Cat.No. 5698 - 1-Methyl-D-tryptophan | C12H14N2O2 | CAS No. 110117-83-4
Description: Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names: 1MT
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data

M. Wt 218.25
Formula C12H14N2O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 110117-83-4
PubChem ID 405012
InChI Key ZADWXFSZEAPBJS-SNVBAGLBSA-N
Smiles CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.09 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.82 mL
5 mM 0.92 mL 4.58 mL 9.16 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327 PMID: 26243621

Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439 PMID: 24587363


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Keywords: 1 MT Indoleamine 2,3-dioxygenase IDO inhibitors inhibits cancer immunology 1MT IDO

Citations for 1-Methyl-D-tryptophan

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Literature in this Area

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Pathways for 1-Methyl-D-tryptophan

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