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Biological Activity for 1-Methyl-D-tryptophan
1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.
Technical Data for 1-Methyl-D-tryptophan
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 1-Methyl-D-tryptophan
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.09||5 with gentle warming|
Preparing Stock Solutions for 1-Methyl-D-tryptophan
The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||91.64 mL||458.19 mL||916.38 mL|
|0.25 mM||18.33 mL||91.64 mL||183.28 mL|
|0.5 mM||9.16 mL||45.82 mL||91.64 mL|
|2.5 mM||1.83 mL||9.16 mL||18.33 mL|
Product Datasheets for 1-Methyl-D-tryptophan
References for 1-Methyl-D-tryptophan
References are publications that support the biological activity of the product.
Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327 PMID: 26243621
Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439 PMID: 24587363
If you know of a relevant reference for 1-Methyl-D-tryptophan, please let us know.
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Keywords: 1-Methyl-D-tryptophan, 1-Methyl-D-tryptophan supplier, 1, MT, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, 1MT, 2,3, dioxygenase, Immune, Checkpoints, 5698, Tocris Bioscience
Citations for 1-Methyl-D-tryptophan
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.
Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.