Pricing Availability   Qty
Description: Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names: 1MT
Purity: ≥97% (HPLC)
Citations (1)
Literature (3)

Biological Activity for 1-Methyl-D-tryptophan

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data for 1-Methyl-D-tryptophan

M. Wt 218.25
Formula C12H14N2O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 110117-83-4
PubChem ID 405012
Smiles CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Methyl-D-tryptophan

Solvent Max Conc. mg/mL Max Conc. mM
water 1.09 5 with gentle warming

Preparing Stock Solutions for 1-Methyl-D-tryptophan

The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 91.64 mL 458.19 mL 916.38 mL
0.25 mM 18.33 mL 91.64 mL 183.28 mL
0.5 mM 9.16 mL 45.82 mL 91.64 mL
2.5 mM 1.83 mL 9.16 mL 18.33 mL

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Product Datasheets for 1-Methyl-D-tryptophan

Certificate of Analysis / Product Datasheet
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References for 1-Methyl-D-tryptophan

References are publications that support the biological activity of the product.

Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327 PMID: 26243621

Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439 PMID: 24587363

If you know of a relevant reference for 1-Methyl-D-tryptophan, please let us know.

View Related Products by Product Action

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Keywords: 1-Methyl-D-tryptophan, 1-Methyl-D-tryptophan supplier, 1, MT, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, 1MT, 2,3, dioxygenase, Immune, Checkpoints, 5698, Tocris Bioscience

1 Citation for 1-Methyl-D-tryptophan

Citations are publications that use Tocris products. Selected citations for 1-Methyl-D-tryptophan include:

Howard L et al (2019) Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci 22 729-740 PMID: 30962630

Do you know of a great paper that uses 1-Methyl-D-tryptophan from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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