1-BCP

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Cat.No. 1048 - 1-BCP | C13H15NO3 | CAS No. 34023-62-6
Description: Modulates AMPA-mediated responses
Chemical Name: 1-(1,3-Benzodioxol-5-ylcarbonyl)piperidine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

A centrally active selective potentiator of AMPA-mediated responses. Facilitates memory retention in rats.

Technical Data

M. Wt 233.27
Formula C13H15NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 34023-62-6
PubChem ID 1370
InChI Key BXBNADAPIHHXJQ-UHFFFAOYSA-N
Smiles O=C(N1CCCCC1)C1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 233.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.29 mL 21.43 mL 42.87 mL
5 mM 0.86 mL 4.29 mL 8.57 mL
10 mM 0.43 mL 2.14 mL 4.29 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Arai et al (1994) A centrally active drug that modulates AMPA receptor gated currents. Brain Res. 638 343 PMID: 7911064

Desai et al (1995) 1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices. Neuropharmacology 34 141 PMID: 7542369

Vanove (1997) Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion. Eur.J.Pharmacol. 332 115 PMID: 9286612

Yamada et al (1998) AMPA receptor activation potentiated by the AMPA modulator 1-BCP is toxic to cultured rat hippocampal neurons. Neurosci.Lett. 249 119 PMID: 9682831


If you know of a relevant reference for 1-BCP, please let us know.

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Keywords: 1-BCP, supplier, Modulates, AMPA-mediated, responses, Glutamate, Receptors, iGlur, Ionotropic, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience

Citations for 1-BCP

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