AS 19

Cat. No. 1968

AS 19 C18H25N3 [1000578-26-6]

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Chemical Name: (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin

Biological Activity

Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Horiguchi et al (2011) The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 338 605. PMID: 21558435.

Perez-Garcia et al (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav.Brain Res. 169 83. PMID: 16480781.

Perez-Garcia and Meneses (2005) Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 163 136. PMID: 15936093.

If you know of a relevant reference for AS 19 please let us know.

Citations are publications that use Tocris products. Selected citations for AS 19 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Neuropsychopharmacology 3 e00103. PMID: 25692021.

Do you know of a great paper that uses AS 19 from Tocris? If so please let us know.

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Keywords: AS 19, supplier, potent, 5-HT7, agonists, serotonin, receptors, 5-Hydroxytryptamine, agonist, AS19, Tocris Bioscience, 5-HT7 Receptor Agonist products

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