N-Formyl-Met-Leu-Phe

Cat. No. 1921

N-Formyl-Met-Leu-Phe N-Formyl-Met-Leu-Phe

Price and Availability

For N-Formyl-Met-Leu-Phe pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: fMLP

Biological Activity

Endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.

Technical Data

M.Wt:
437.55
Formula:
C21H31N3O5S
Sequence:
MLF

(Modifications: Met-1 = N-formyl-Met)

Solubility:
Soluble to 4.38 mg/ml in DMSO
Storage:
Desiccate at -20°C
CAS No:
59880-97-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012. PMID: 10960471.

Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73. PMID: 6325345.

Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39. PMID: 45788.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for N-Formyl-Met-Leu-Phe include:

Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153. PMID: 19892704.

Do you know of a great paper that uses N-Formyl-Met-Leu-Phe from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: N-Formyl-Met-Leu-Phe, supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, Tocris Bioscience, Formyl Peptide Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

New Products in this Area

MSG 606

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Neuropeptide S (Mouse)

Potent endogenous neuropeptide S receptor (NPSR) agonist

ML 382

MrgX1 (SNSR4) positive allosteric modulator

K-(D-1-Nal)-FwLL-NH2

High affinity and potent ghrelin receptor inverse agonist

Neuropeptide S (Rat)

Potent endogenous neuropeptide S receptor agonist

Neuropeptide S (human)

Potent endogenous neuropeptide S receptor agonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.