Cat. No. 1921
Alternative Name: fMLP
Biological ActivityEndogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.
(Modifications: Met-1 = N-formyl-Met)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012. PMID: 10960471.
Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73. PMID: 6325345.
Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39. PMID: 45788.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for N-Formyl-Met-Leu-Phe include:
Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153. PMID: 19892704.
Do you know of a great paper that uses N-Formyl-Met-Leu-Phe from Tocris? If so please let us know.
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Keywords: N-Formyl-Met-Leu-Phe, supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, Tocris Bioscience, Formyl Peptide Receptor Agonist products
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