Nemonapride

Cat. No. 1746

Nemonapride C21H26ClN3O2 [75272-39-8]

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Alternative Names: YM 09151, YM 09151-2

Chemical Name: cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide

Biological Activity

Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors.

Technical Data

M.Wt:
387.91
Formula:
C21H26ClN3O2
Solubility:
Soluble to 20 mM in ethanol and to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
75272-39-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Assie et al (1997) 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur.J.Pharmacol. 334 141. PMID: 9369342.

Ujike et al (1996) [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes. Neuroreport 7 1057. PMID: 8804051.

Terai et al (1983) Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn.J.Pharmacol. 33 749. PMID: 6138453.

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Keywords: Nemonapride, supplier, 5-HT1A, agonists, potent, D2-like, dopamine, antagonists, Serotonin, Receptors, Non-Selective, dopaminergic, YM09151, YM09151-2, Tocris Bioscience, Non-selective Dopamine Antagonist products

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