PF 3758309 dihydrochloride

Cat. No. 6005new

PF 3758309 dihydrochloride C25H30N8OS.2HCl

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Chemical Name: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride

Biological Activity

Potent PAK4 inhibitor (IC50 = 1.3 nM; Kd = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3758309 is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
563.55
Formula:
C25H30N8OS.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Murray et al (2010) Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc.Natl.Acad.Sci.U.S.A. 107 9446. PMID: 20439741.

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Keywords: PF 3758309 dihydrochloride, supplier, PF3758309, dihydrochloride, Potent, PAK4, inhibitors, inhibits, orally, available, 89044_15_0, chemical, probes, Tocris Bioscience, P21-activated Kinases Inhibitor products

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