666-15

Cat. No. 5661

666-15 C33H30ClN3O5.HCl [1433286-70-4]

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Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

Biological Activity

Potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.

Technical Data

M.Wt:
620.52
Formula:
C33H30ClN3O5.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1433286-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Xie et al (2015) Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity J.Med.Chem. 58 5075. PMID: 26023867.

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Keywords: 666-15, supplier, cyclic, adenosine, monophosphate, cAMP, response, element, binding, protein, CREB, inhibitors, inhibits, breast, cancer, potent, selective, Tocris Bioscience, Other Transcription Factor products

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