BMS 265246

Cat. No. 5654new

BMS 265246 C18H17F2N3O2 [582315-72-8]

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Chemical Name: (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone

Biological Activity

Potent cdk1/2 inhibitor (IC50 values are 6, 9 and 230 nM for cdk1, cdk2 and cdk4, respectively). Inhibits proliferation of HCT-116 colon cancer cells in vitro.

Technical Data

Soluble to 50 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Misra et al (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 13 2405. PMID: 12824044.

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Keywords: BMS 265246, supplier, BMS265246, potent, cyclin, dependent, kinases, cdk1, cdk2, inhibitors, inhibits, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

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