Cat. No. 5654
Chemical Name: (4-Butoxy-1H-pyrazolo[3,4-b]pyridin
Biological ActivityPotent cdk1/2 inhibitor (IC50 values are 6, 9 and 230 nM for cdk1, cdk2 and cdk4, respectively). Inhibits proliferation of HCT-116 colon cancer cells in vitro.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Misra et al (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 13 2405. PMID: 12824044.
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Keywords: BMS 265246, supplier, BMS265246, potent, cyclin, dependent, kinases, cdk1, cdk2, inhibitors, inhibits, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products
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