BMS 265246

Cat. No. 5654new

BMS 265246 C18H17F2N3O2 [582315-72-8]

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Chemical Name: (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone

Biological Activity

Potent cdk1/2 inhibitor (IC50 values are 6, 9 and 230 nM for cdk1, cdk2 and cdk4, respectively). Inhibits proliferation of HCT-116 colon cancer cells in vitro.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.

Technical Data

M.Wt:
345.34
Formula:
C18H17F2N3O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
582315-72-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Misra et al (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 13 2405. PMID: 12824044.

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Keywords: BMS 265246, supplier, BMS265246, potent, cyclin, dependent, kinases, cdk1, cdk2, inhibitors, inhibits, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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