I-BRD9

Cat. No. 5591

I-BRD9 C22H22F3N3O3S2 [1714146-59-4]

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Chemical Name: 5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide

Biological Activity

Potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. Downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-BRD9 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-BRD9 is reviewed on the chemical probes website.

Technical Data

M.Wt:
497.55
Formula:
C22H22F3N3O3S2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1714146-59-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Theodoulou et al (2015) Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. J.Med.Chem 59 1425. PMID: 25856009.

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Keywords: I-BRD9, supplier, bromodomains, containing, protein, extra, terminal, inhibits, inhibitors, potent, selective, downregulates, downregulation, sgc, structural, genomics, consortium, Tocris Bioscience, Bromodomain Inhibitor products

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