Quin C1

Cat. No. 5583

Quin C1 C26H27N3O4 [786706-21-6]

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Chemical Name: 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide

Biological Activity

Potent and selective FPR2 agonist (EC50 = 40 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Corminboeuf et al (2014) FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 58 537. PMID: 25365541.

Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976. PMID: 17652444.

If you know of a relevant reference for Quin C1 please let us know.

Citations are publications that use Tocris products. Selected citations for Quin C1 include:

Ma et al (2015) Agonist and antagonist effects of aripiprazole on D2-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone. Int J Neuropsychopharmacol 18. PMID: 25522390.

Do you know of a great paper that uses Quin C1 from Tocris? If so please let us know.

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Keywords: Quin C1, supplier, QuinC1, potent, selective, agonists, agonism, FPR2, FPRL1, formyl, peptide, receptor-like, 1, inflammation, anti-inflammatory, Tocris Bioscience, Formyl Peptide Receptor Agonist products

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