Cat. No. 5308
Chemical Name: 4-[3-(1-Methylethyl)-5-(6-phenyl-3-
Biological ActivityPotent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Harada et al (2012) A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease. Eur.J.Pharmacol. 685 59. PMID: 22542656.
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Keywords: ASP 2535, supplier, ASP2535, potent, selective, glycine, transporters, GlyT1, inhibitors, inhibits, schizophrenia, alzheimer's, disease, Tocris Bioscience, Glycine Transporter Inhibitor products
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