GSK 137647

Cat. No. 5257

GSK 137647 C16H19NO3S [349085-82-1]

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Chemical Name: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide

Biological Activity

Potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
305.39
Formula:
C16H19NO3S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
349085-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100. PMID: 24881566.

Martin et al (2012) Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J.Lipid Res. 53 2256. PMID: 22904345.

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Keywords: GSK 137647, supplier, GSK137647, Free, fatty, acid, receptor, 4, diabetes, potent, and, selective, FFA4, GPR120, agonist, Tocris Bioscience, Free Fatty Acid Receptor Agonist products

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