AH 7614

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Cat.No. 5256 - AH 7614 | C20H17NO3S | CAS No. 6326-06-3
Description: Selective FFA4 (GPR120) antagonist
Chemical Name: 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

AH 7614 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 351.42
Formula C20H17NO3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6326-06-3
PubChem ID 233085
InChI Key OZCQEUZTOAAWDK-UHFFFAOYSA-N
Smiles CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100 PMID: 24881566


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Keywords: AH7614 selective free fatty acid 4 FFA4 receptor antagonist GPR120 Free Fatty Acid Receptors

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