Cat. No. 4952
Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitr
Biological ActivityPotent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Burnham et al (2006) Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats. Br.J.Pharmacol. 148 434. PMID: 16682967.
Ayabe et al (2002) Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J.Biol.Chem. 277 3793. PMID: 11724775.
Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci.U.S.A. 97 8151. PMID: 10884437.
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Keywords: TRAM 39, supplier, TRAM39, potent, intermediate, conductance, calcium, Ca2+, actiavted, potassium, K+, channels, blockers, blocks, KCa3.1, IKCa1, ion, channels, Tocris Bioscience, Calcium-Activated Potassium (KCa) Channel Blocker products
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