Sulfidefluor 7 AM

Cat. No. 4943

Sulfidefluor 7 AM C31H23N7O12 [1416872-50-8]

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Chemical Name: N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[(3',6'-diazido-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]glycine (acetyloxy)methyl ester

Biological Activity

Reported to be a hydrogen sulphide (H2S) fluorescent probe. Contains an acetoxymethyl ester, which enhances cell permeability and is hydrolyzed inside the cell to trap the probe. Used to visualize VEGF-induced H2S production in human umbilical vein endothelial cells (HUVECS). Excitation wavelength ~ 495 nm; emission maximum ~ 520 nm.

Licensing Information

Sold under license from the Regents of the University of California

Technical Data

M.Wt:
685.55
Formula:
C31H23N7O12
Solubility:
Soluble to 20 mM in DMSO
Storage:
Store at -20°C
CAS No:
1416872-50-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lin et al (2013) Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production. Proc.Natl.Acad.Sci.USA. 110 7131. PMID: 23589874.

Lippert et al (2011) Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. J.Am.Chem.Soc. 133 10078. PMID: 21671682.

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Keywords: Sulfidefluor 7 AM, supplier, hydrogen, sulphide, H2S, fluorescent, probe, Tocris Bioscience, Fluorescent Probe products

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