Clozapine N-oxide

Cat. No. 4936

Clozapine N-oxide C18H19ClN4O [34233-69-7]

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Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Biological Activity

Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4 DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in water
>98 %
Store at RT


Other Information

  • This product contains 1 molar equivalent of ethanol.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Zaman et al (2014) LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J.Neurosci. 34 140. PMID: 24381275.

Armbruster et al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc.Natl.Acad.Sci.U.S.A. 104 5163. PMID: 17360345.

Eiermann et al (1997) The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br.J.Clin.Pharmacol. 44 439. PMID: 9384460.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Clozapine N-oxide include:

D'Agostino et al (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. PLoS Biol 5. PMID: 26974347.

Do you know of a great paper that uses Clozapine N-oxide from Tocris? If so please let us know.

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