Cat. No. 4936
Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-pip
Biological ActivityMetabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4 DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zaman et al (2014) LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J.Neurosci. 34 140. PMID: 24381275.
Armbruster et al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc.Natl.Acad.Sci.U.S.A. 104 5163. PMID: 17360345.
Eiermann et al (1997) The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br.J.Clin.Pharmacol. 44 439. PMID: 9384460.
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Citations are publications that use Tocris products. Selected citations for Clozapine N-oxide include:
D'Agostino et al (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. PLoS Biol 5. PMID: 26974347.
Pina and Cunningham et al (2016) Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit Neurobiology of Learning and Memory 137 83. PMID: 27866960.
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Keywords: Clozapine N-oxide, supplier, clozapine, metabolite, 5HT2A/2C, non-selective, receptors, serotonin, 5HT2C, 5HT2, 5HT2A, dopaminergic, dopamine, antagonists, D4, clozapine-N-oxide, DREADDs, muscarnic, receptors, designer, receptors, CNO, Tocris Bioscience, DREADD Ligand Activator products
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