BI 6015

Cat. No. 4641

BI 6015 C15H13N3O4S [93987-29-2]

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Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole

Biological Activity

Hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kiselyuk et al (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem.Biol. 19 806. PMID: 22840769.

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Keywords: BI 6015, supplier, BI6015, Hepatocyte, nuclear, factor, 4, alpha, HNF4a, HNF4α, antagonists, DNA, binding, cancer, Tocris Bioscience, Other Transcription Factor products

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