Cat. No. 4641
Chemical Name: 2-Methyl-1-[(2-methyl-5-nitrophenyl
Biological ActivityHepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kiselyuk et al (2012) HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem.Biol. 19 806. PMID: 22840769.
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Citations are publications that use Tocris products. Selected citations for BI 6015 include:
Levy et al (2016) Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection Nature Chemical Biology 12 1037. PMID: 27723751.
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Keywords: BI 6015, supplier, BI6015, Hepatocyte, nuclear, factor, 4, alpha, HNF4a, HNF4α, antagonists, DNA, binding, cancer, Tocris Bioscience, Other Transcription Factor products