Cat. No. 3676
Chemical Name: 2-(2-Chlorophenyl)-3-(4-chloropheny
Biological ActivityPotent and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Dow et al (2009) Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. J.Med.Chem. 52 2652. PMID: 19351113.
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Citations are publications that use Tocris products. Selected citations for PF 514273 include:
Rozenfeld et al (2011) AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 30 2350. PMID: 21540834.
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Keywords: PF 514273, supplier, Potent, and, selective, CB1, agonists, cannabinoids, Receptors, PF514273, cb1r, Tocris Bioscience, CB1 Receptor Antagonist products