Vinorelbine ditartrate

Cat. No. 3401

Vinorelbine ditartrate C45H54N4O8.2C4H6O6 [125317-39-7]

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Alternative Name: Navelbine

Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

Biological Activity

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

M.Wt:
1079.1
Formula:
C45H54N4O8.2C4H6O6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
125317-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol.Cancer Ther. 2 427. PMID: 12748304.

Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol.Pharmacol. 60 225. PMID: 11408618.

Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475. PMID: 9316630.

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Keywords: Vinorelbine ditartrate, supplier, Selective, mitotic, microtubule, antagonists, Tau, Tubulin, chemotherapeutics, Tocris Bioscience, Microtubule products

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