Vinorelbine ditartrate

Cat. No. 3401

Vinorelbine ditartrate C45H54N4O8.2C4H6O6 [125317-39-7]

Price and Availability

For Vinorelbine ditartrate pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Navelbine

Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

Biological Activity

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol.Cancer Ther. 2 427. PMID: 12748304.

Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol.Pharmacol. 60 225. PMID: 11408618.

Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475. PMID: 9316630.

If you know of a relevant reference for Vinorelbine ditartrate please let us know.

Citations are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

Mavroeidis et al (2015) Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Front Cell Neurosci 47 455. PMID: 26095084.

Do you know of a great paper that uses Vinorelbine ditartrate from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Vinorelbine ditartrate, supplier, Selective, mitotic, microtubule, antagonists, Tau, Tubulin, chemotherapeutics, Tocris Bioscience, Microtubule products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

New Products in this Area

Latrunculin B

Inhibitor of actin polymerization

Sign-up for new product e-alerts
divider line

ISSCR 2017

Win a $1,000 travel grant

ISSCR Travel Grant 2017

Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.