BW-B 70C

Cat. No. 1304

BW-B 70C C17H17FN2O3 [134470-38-5]

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Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea

Biological Activity

Potent, selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.

Technical Data

M.Wt:
316.33
Formula:
C17H17FN2O3
Solubility:
Soluble to 3 mM in ethanol and to 3 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
134470-38-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8. PMID: 8480540.

Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189. PMID: 1793063.

Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109. PMID: 1847758.

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Keywords: BW-B 70C, supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Tocris Bioscience, Lipoxygenase Inhibitor products

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