BW-B 70C

Cat. No. 1304

BW-B 70C C17H17FN2O3 [134470-38-5]

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Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea

Biological Activity

Potent, selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.

Technical Data

Soluble to 3 mM in ethanol and to 3 mM in DMSO
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8. PMID: 8480540.

Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189. PMID: 1793063.

Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109. PMID: 1847758.

If you know of a relevant reference for BW-B 70C please let us know.

Citations are publications that use Tocris products. Selected citations for BW-B 70C include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031. PMID: 22633978.

Do you know of a great paper that uses BW-B 70C from Tocris? If so please let us know.

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Keywords: BW-B 70C, supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Tocris Bioscience, Lipoxygenase Inhibitor products

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