Cat. No. 1031
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1
Biological ActivityA direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cagnotto et al (1996) In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63. PMID: 8905329.
Jenne (1992) Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 239 S2. PMID: 1634907.
Offermeier and van Rooyen (1986) A comparative study of the locomotor activity effects of apomorphine and the 'atypical dopamine agonists' (piribedil and S36080). Life Sci. 38 895. PMID: 3081774.
Merck Index 12 7648.
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Keywords: Piribedil dihydrochloride, supplier, Dopamine, agonist, D2-like, Non-Selective, Receptors, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products