NMDA

Cat. No. 0114

NMDA C5H9NO4 [6384-92-5]

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Chemical Name: N-Methyl-D-aspartic acid

Biological Activity

Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™. Caged version also available (Cat. No 2224).

Technical Data

M.Wt:
147.13
Formula:
C5H9NO4
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
6384-92-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165. PMID: 6112965.

Watkins (1978) Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E 37.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NMDA include:

Reinhard et al (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun 7 11613. PMID: 27194588.

Bell et al (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nat Commun 6 7066. PMID: 25967870.

Bertrand et al (2015) Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR. Cell Death Dis 6 e1924. PMID: 26469972.

Curcio et al (2015) Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis 6 e1645. PMID: 25675305.

Eckel et al (2015) Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity. Neuropharmacology 88 82. PMID: 25245802.

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Glia 63 383. PMID: 25327839.

Iskandrani et al (2015) Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. J Psychopharmacol 29 792. PMID: 25759403.

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget 6 35458. PMID: 26461475.

Aligny et al (2014) Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice. Cell Death Dis 5 e1311. PMID: 24991763.

An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523. PMID: 25393479.

Antoniou et al (2014) PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity. EMBO Rep 15 548. PMID: 24723684.

Chen et al (2014) Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction. Nat Commun 5 5331. PMID: 25354791.

Hsu et al (2014) STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ. Neuropsychopharmacology 39 746. PMID: 24081304.

Lee et al (2014) Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase. Philos Trans R Soc Lond B Biol Sci 369 20130158. PMID: 24298159.

Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Int J Neuropsychopharmacol 17 1943. PMID: 24485144.

Thein et al (2014) CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. PLoS One 9 e91312. PMID: 24614225.

Thein et al (2014) IKK regulates the deubiquitinase CYLD at the postsynaptic density. Biochem Biophys Res Commun 450 550. PMID: 24928390.

Kung et al (2013) Evidence for glutamate as a neuroglial transmitter within sensory ganglia. PLoS One 8 e68312. PMID: 23844184.

Pigott et al (2013) On the selectivity of neuronal NOS inhibitors. Br J Pharmacol 168 1255. PMID: 23072468.

Pooler et al (2013) Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep 14 389. PMID: 23412472.

Selvakumar et al (2013) S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis. Proc Natl Acad Sci U S A 110 1077. PMID: 23277581.

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci 33 11206. PMID: 23825423.

Tupone et al (2013) Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat. J Neurosci 33 14512. PMID: 24005302.

Vicente-Sánchez et al (2013) HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain 6 42. PMID: 24093505.

Yang et al (2013) Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density. PLoS One 8 e71795. PMID: 23967245.

Bahia et al (2012) Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J Neurochem 123 182. PMID: 22804756.

Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186. PMID: 22496564.

Cunningham et al (2012) Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance. Epilepsia 53 1205. PMID: 22686654.

He et al (2012) Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons. FASEB J 26 334. PMID: 21982949.

Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601. PMID: 22197913.

Huang et al (2012) Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. PLoS One 7 e30662. PMID: 22292013.

Niwa et al (2012) Gephyrin-independent GABA(A)R mobility and clustering during plasticity. PLoS One 7 e36148. PMID: 22563445.

Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12. PMID: 22877698.

Rodríguez-Muñoz et al (2012) The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control. Neuropsychopharmacology 37 338. PMID: 21814188.

Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521. PMID: 21850438.

Udagawa et al (2012) Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell 47 253. PMID: 22727665.

Wang et al (2012) Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci 32 9773. PMID: 22815492.

Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051. PMID: 21123660.

Fontainhas et al (2011) Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission. PLoS One 6 e15973. PMID: 21283568.

Li et al (2011) Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages. J Neuroinflammation 8 15. PMID: 21324129.

Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. J Neurosci 31 3077. PMID: 21414928.

Mahajan et al (2011) Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 189 305. PMID: 21620933.

Meissirel et al (2011) VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A 108 13782. PMID: 21804034.

Wang and Green (2011) Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro. J Neurosci 31 7938. PMID: 21613508.

Yang et al (2011) SynGAP moves out of the core of the postsynaptic density upon depolarization. Neuroscience 192 132. PMID: 21736925.

Baron et al (2010) NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity. Cell Death Differ 17 860. PMID: 19911010.

Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606. PMID: 20826795.

Marignier et al (2010) Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury. Brain 133 2578. PMID: 20688809.

Pansiot et al (2010) Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. PLoS One 5 e10916. PMID: 20532231.

Citri et al (2009) N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system. Eur J Neurosci 30 1443. PMID: 19821836.

Roselli et al (2009) Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS One 4 e6011. PMID: 19547699.

Furness et al (2008) A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience 157 80. PMID: 18805467.

Iwasato et al (2008) Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. J Neurosci 28 5931. PMID: 18524897.

Wayman et al (2008) An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci U S A 105 9093. PMID: 18577589.

Davidkova and Carroll (2007) Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus. J Neurosci 27 13273. PMID: 18045921.

Holman et al (2007) Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices. Neuropharmacology 52 92. PMID: 16815481.

Iida et al (2007) Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites. Mol Cell Biol 27 4388. PMID: 17438139.

Sossa et al (2007) AMPAR exocytosis through NO modulation of PICK1. Neuropharmacology 53 92. PMID: 17555774.

Ziskin et al (2007) Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci 10 321. PMID: 17293857.

Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591. PMID: 16920620.

Smith et al (2006) cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J Neurosci 26 2391. PMID: 16510716.

Lea et al (2005) Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Br J Pharmacol 145 527. PMID: 15821750.

Lenz and Avruch (2005) Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem 280 38121. PMID: 16183639.

Lesne et al (2005) Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity. J Biol Chem 280 24941. PMID: 15797869.

Nakayama et al (2005) Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses. J Neurosci 25 4040. PMID: 15843606.

Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci 25 4288. PMID: 15858055.

Srinivasan et al (2004) Cell type-specific interleukin-1beta signaling in the CNS. J Neurosci 24 6482. PMID: 15269258.

Morante-Oria et al (2003) Subpallial origin of a population of projecting pioneer neurons during corticogenesis. Proc Natl Acad Sci U S A 100 12468. PMID: 14523241.

Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A 97 11593. PMID: 11016958.

O'Leary et al (2000) Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131 1429. PMID: 11090117.

Do you know of a great paper that uses NMDA from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: NMDA, supplier, Selective, NMDA, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Tocris Bioscience, NMDA Receptor Agonist products

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