MNI-caged-NMDA

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Cat.No. 2224 - MNI-caged-NMDA | C14H17N3O6 | CAS No. 1227675-52-6
Description: Caged NMDA
Alternative Names: 4-Methoxy-7-nitroindolinyl-caged N-methyl-D-aspartic acid
Chemical Name: (R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

NMDA (Cat.No. 0114) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Stoichiometrically releases chirally pure NMDA. Suitable for uncaging with 300-380 nm excitation. Improved localization can be achieved by uncaging at 405 nm (with mM concentration of caged compound in the bath solution). Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.

Licensing Information

Sold under license from the UK Medical Research Council

Technical Data

M. Wt 323.3
Formula C14H17N3O6
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1227675-52-6
PubChem ID 57369294
InChI Key MUCRWOILMOHLGD-SECBINFHSA-N
Smiles O=C(C[C@H](C(O)=O)NC)N2C1=C([N+]([O-])=O)C=CC(OC)=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.33 100
water 1.62 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 323.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.47 mL 30.93 mL
5 mM 0.62 mL 3.09 mL 6.19 mL
10 mM 0.31 mL 1.55 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624 PMID: 22609535


If you know of a relevant reference for MNI-caged-NMDA, please let us know.

Keywords: MNI-caged-NMDA, supplier, Caged, NMDA, Compounds, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, MNI-NMDA, 4-Methoxy-7-nitroindolinyl-caged, N-methyl-D-aspartic, acid, NMDA, Receptors, Caged, Glutamate, Compounds, NMDA, Receptors, Tocris Bioscience

1 Citation for MNI-caged-NMDA

Citations are publications that use Tocris products. Selected citations for MNI-caged-NMDA include:

Zhang et al (2016) Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Nat.Commun. 7 12650 PMID: 27586999


Do you know of a great paper that uses MNI-caged-NMDA from Tocris? If so please let us know.

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