GW 3965 hydrochloride
Cat. No. 2474
Chemical Name: 3-[3-[[[2-Chloro-3-(trifluoromethyl
Biological ActivitySelective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ (EC50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Leik et al (2007) GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. Br.J.Pharmacol. 151 450. PMID: 17420776.
Collins et al (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J.Med.Chem. 45 1963. PMID: 11985463.
Joseph et al (2002) Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proc.Natl.Acad.Sci.USA 99 7604.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for GW 3965 hydrochloride include:
Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283. PMID: 24812009.
Gabbi et al (2012) Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β. Proc Natl Acad Sci U S A 109 3030. PMID: 22323586.
Do you know of a great paper that uses GW 3965 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: GW 3965 hydrochloride, supplier, non-steroidal, liver, X, receptor, LXR, agonists, FXR, Receptors, Farnesoid, LXR-like, GW3965, hydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, LXR-like Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Steroid receptor coactivator 3 (SRC-3) inhibitorSR 0987
T cell-specific RORγ (RORγt) agonistWAY 252623
Potent LXR agonistSR 9009
Rev-Erbα/β agonistSR 9238
Potent and selective LXR inverse agonistIP7e
Potent Nurr1 activatorBexarotene
Potent and selective RXR agonistGSK 2033
Potent LXR antagonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.