GW 3965 hydrochloride

Cat. No. 2474

GW 3965 hydrochloride C33H31NO3ClF3.HCl [405911-17-3]

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Chemical Name: 3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride

Biological Activity

Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ (EC50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
618.51
Formula:
C33H31NO3ClF3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
405911-17-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Leik et al (2007) GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. Br.J.Pharmacol. 151 450. PMID: 17420776.

Collins et al (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J.Med.Chem. 45 1963. PMID: 11985463.

Joseph et al (2002) Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proc.Natl.Acad.Sci.USA 99 7604.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GW 3965 hydrochloride include:

Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283. PMID: 24812009.

Gabbi et al (2012) Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β. Proc Natl Acad Sci U S A 109 3030. PMID: 22323586.

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Keywords: GW 3965 hydrochloride, supplier, non-steroidal, liver, X, receptor, LXR, agonists, FXR, Receptors, Farnesoid, LXR-like, GW3965, hydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, LXR-like Receptor Agonist products

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