Exendin-3 (9-39) amide
Cat. No. 2081
Biological ActivityPotent and selective GLP-1 receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC50 = 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.
(Modifications: Ser-31 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Turton et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69. PMID: 8538742.
Goke et al (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells. J.Biol.Chem. 268 19650. PMID: 8396143.
Thorens et al (1993) Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42 1678. PMID: 8405712.
Raufman et al (1991) Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. J.Biol.Chem. 266 2897. PMID: 1704369.
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Citations are publications that use Tocris products. Selected citations for Exendin-3 (9-39) amide include:
Maniscalco et al (2015) Negative Energy Balance Blocks Neural and Behavioral Responses to Acute Stress by "Silencing" Central Glucagon-Like Peptide 1 Signaling in Rats. Emerg Microbes Infect 35 10701. PMID: 26224855.
Gaitonde et al (2012) The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition. J Surg Res 178 33. PMID: 22929182.
Do you know of a great paper that uses Exendin-3 (9-39) amide from Tocris? If so please let us know.
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Keywords: Exendin-3 (9-39) amide, supplier, Potent, GLP-1, receptor, antagonists, Receptors, Glucagon-Like, Peptide, 1, Tocris Bioscience, Glucagon-Like Peptide 1 Receptor Antagonist products