Cat. No. 1061
Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octah
Biological ActivitySelective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
Licensing InformationSold with the permission of Eli Lilly and Company
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sullivan et al (1998) Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience 83 781. PMID: 9483561.
Levant et al (1996) Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J.Pharmacol.Exp.Ther. 278 145. PMID: 8764345.
Seeman and Van Tol (1994) Dopamine receptor pharmacology. Trends Pharmacol.Sci. 15 264. PMID: 7940991.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:
Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.
Ahmadiantehrani and Ron (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem. PMID: 23373701.
Gantz et al (2011) Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci 31 12629. PMID: 21880923.
Burgess et al (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295. PMID: 21061851.
Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci 13 958. PMID: 20601948.
Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068. PMID: 19729052.
Kitada et al (2007) Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A 104 11441. PMID: 17563363.
Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842. PMID: 17923483.
Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520. PMID: 12970091.
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Keywords: (-)-Quinpirole hydrochloride, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products