(-)-Quinpirole hydrochloride

Cat. No. 1061

(-)-Quinpirole hydrochloride C13H21N3.HCl [85798-08-9]

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Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride

Biological Activity

Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data

M.Wt:
255.79
Formula:
C13H21N3.HCl
Solubility:
Soluble to 100 mM in water and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
85798-08-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Sullivan et al (1998) Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience 83 781. PMID: 9483561.

Levant et al (1996) Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J.Pharmacol.Exp.Ther. 278 145. PMID: 8764345.

Seeman and Van Tol (1994) Dopamine receptor pharmacology. Trends Pharmacol.Sci. 15 264. PMID: 7940991.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:

Borgs et al (2016) Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects Scientific Reports 6 33377. PMID: 27640816.

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Nat Neurosci 112 8124. PMID: 26080439.

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Proc Natl Acad Sci U S A 11 2057. PMID: 26649942.

Xing et al (2015) Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Neuropsychopharmacology 9 310. PMID: 26388722.

Ahmadiantehrani and Ron (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem. PMID: 23373701.

Ferraro et al (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. J Neurosci 37 1856. PMID: 22453136.

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Autophagy 35 507. PMID: 22304466.

Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Eur J Neurosci 37 321. PMID: 21956448.

Gantz et al (2011) Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci 31 12629. PMID: 21880923.

Yoon et al (2011) Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation. Neuropsychopharmacology 286 15641. PMID: 21454669.

Burgess et al (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295. PMID: 21061851.

Deng et al (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. J Biol Chem 13 1128. PMID: 20711186.

Goffin et al (2010) Dopamine-dependent tuning of striatal inhibitory synaptogenesis. Neuron 30 2935. PMID: 20181591.

Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci 13 958. PMID: 20601948.

Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068. PMID: 19729052.

González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. PLoS One 53 439. PMID: 17270739.

Kitada et al (2007) Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A 104 11441. PMID: 17563363.

Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842. PMID: 17923483.

Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520. PMID: 12970091.

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