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Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 212.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.71 mL||23.56 mL||47.12 mL|
|5 mM||0.94 mL||4.71 mL||9.42 mL|
|10 mM||0.47 mL||2.36 mL||4.71 mL|
|50 mM||0.09 mL||0.47 mL||0.94 mL|
References are publications that support the biological activity of the product.
Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 25 1107 PMID: 11055748
Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683 PMID: 14704463
Gluck et al (2004) Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713 PMID: 15168218
Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98 PMID: 17255467
If you know of a relevant reference for Zonisamide, please let us know.
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Keywords: Zonisamide, Zonisamide supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, AD, 810, CI, 912, Other, Channel, Modulators, Miscellaneous, Glutamate, GABAB, Receptors, 2625, Tocris Bioscience
Citations for Zonisamide
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Reviews for Zonisamide
Average Rating: 5 (Based on 1 Review.)
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Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.
Literature in this Area
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