You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 212.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.71 mL||23.56 mL||47.12 mL|
|5 mM||0.94 mL||4.71 mL||9.42 mL|
|10 mM||0.47 mL||2.36 mL||4.71 mL|
|50 mM||0.09 mL||0.47 mL||0.94 mL|
References are publications that support the biological activity of the product.
Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 25 1107 PMID: 11055748
Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683 PMID: 14704463
Gluck et al (2004) Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713 PMID: 15168218
Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98 PMID: 17255467
If you know of a relevant reference for Zonisamide, please let us know.
View Related Products by Target
Keywords: Zonisamide, Zonisamide supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, AD, 810, CI, 912, Other, Channel, Modulators, Miscellaneous, Glutamate, GABAB, Receptors, 2625, Tocris Bioscience
Citations for Zonisamide
Citations are publications that use Tocris products.
Currently there are no citations for Zonisamide. Do you know of a great paper that uses Zonisamide from Tocris? Please let us know.
Reviews for Zonisamide
Average Rating: 5 (Based on 1 Review.)
Have you used Zonisamide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells