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Cat.No. 2625 - Zonisamide | C8H8N2O3S | CAS No. 68291-97-4
Description: Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)
Alternative Names: AD 810, CI 912
Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
Purity: ≥99% (HPLC)

Biological Activity

Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Compound Libraries

Zonisamide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 212.22
Formula C8H8N2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 68291-97-4
PubChem ID 5734
Smiles NS(=O)(=O)CC1=NOC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1.1eq. NaOH 21.22 100
DMSO 21.22 100
ethanol 5.31 25
water 2.12 10

Preparing Stock Solutions

The following data is based on the product molecular weight 212.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.56 mL 47.12 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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References are publications that support the products' biological activity.

Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. Neurochem.Res. 25 1107 PMID: 11055748

Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683 PMID: 14704463

Gluck et al (2004) Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713 PMID: 15168218

Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98 PMID: 17255467

If you know of a relevant reference for Zonisamide, please let us know.

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