Pricing Availability   Qty
Description: Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)
Alternative Names: AD 810,CI 912
Chemical Name: 1,2-Benzisoxazole-3-methanesulfonamide
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for Zonisamide

Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Compound Libraries for Zonisamide

Zonisamide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Zonisamide

M. Wt 212.22
Formula C8H8N2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 68291-97-4
PubChem ID 5734
Smiles NS(=O)(=O)CC1=NOC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zonisamide

Solvent Max Conc. mg/mL Max Conc. mM
water 2.12 10
DMSO 21.22 100

Preparing Stock Solutions for Zonisamide

The following data is based on the product molecular weight 212.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.56 mL 47.12 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Zonisamide

References are publications that support the biological activity of the product.

Tokumaru et al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res. 25 1107 PMID: 11055748

Sobieszek et al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683 PMID: 14704463

Gluck et al (2004) Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713 PMID: 15168218

Huang et al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98 PMID: 17255467

If you know of a relevant reference for Zonisamide, please let us know.

Keywords: Zonisamide, Zonisamide supplier, AD810, CI912, Antiepileptic, broad, spectrum, anticonvulsant, blocks, blockers, voltage-sensitive, Na+, sodium, T-type, Ca2+, calcium, channels, stimulates, stimulators, BKCa, calcium-activated, potassium, GABA, glutamate, monoamine, neurotransmission, inhibits, inhibitors, lipid, AD, 810, CI, 912, Other, Channel, Modulators, Miscellaneous, Glutamate, GABAB, Receptors, 2625, Tocris Bioscience

Citations for Zonisamide

Citations are publications that use Tocris products.

Currently there are no citations for Zonisamide. Do you know of a great paper that uses Zonisamide from Tocris? Please let us know.

Reviews for Zonisamide

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Zonisamide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities.
By Anonymous on 02/27/2019
Species: Human

Zonisamide was used on Cav3.1 and Cav3.2 channel to understand their blocking capacities at increasing concentrations.We aimed to decrease calcium conductance through the channels as increase leads to increased depolarization and excitability.

review image