Zoniporide dihydrochloride

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Cat.No. 2727 - Zoniporide dihydrochloride | C17H16N6O.2HCl | CAS No. 241799-10-0
Description: Selective NHE1 inhibitor
Alternative Names: CP 597396
Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries

Zoniporide dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 393.27
Formula C17H16N6O.2HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 241799-10-0
PubChem ID 22267855
InChI Key ARZNPJAGKWHEHT-UHFFFAOYSA-N
Smiles O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.93 10
DMSO 39.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.43 mL
5 mM 0.51 mL 2.54 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Knight et al (2001) A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297 254 PMID: 11259552

Marala et al (2002) Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur.J.Pharmacol. 451 37 PMID: 12223226

Clements-Jewery et al (2004) Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 142 57 PMID: 15037516


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Keywords: Zoniporide dihydrochloride, Zoniporide dihydrochloride supplier, Selective, NHE-1, inhibitors, inhibits, Ion, Pumps, Transporters, Sodium-hydrogen, exchanger, isoform-1, CP597396, CP, 597396, Na+/H+, Exchanger, 2727, Tocris Bioscience

2 Citations for Zoniporide dihydrochloride

Citations are publications that use Tocris products. Selected citations for Zoniporide dihydrochloride include:

Goldman et al (2011) The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. PLoS One 6 e23835 PMID: 21887327

Féraille et al (2014) NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity. PLoS One 9 e87239 PMID: 24466344


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Literature in this Area

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Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure