Zolantidine dimaleate

Pricing Availability   Qty
Description: Potent, centrally active H2 antagonist
Chemical Name: N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine dimaleate
Citations (1)
Literature (1)

Biological Activity for Zolantidine dimaleate

Zolantidine dimaleate is a a potent, selective and brain penetrating H2 receptor antagonist.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for Zolantidine dimaleate

M. Wt 613.68
Formula C22H27N3OS.2C4H4O4
Storage Desiccate at +4°C
CAS Number 104076-39-3
PubChem ID 11957725
Smiles OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C(CNC1=NC2=C(S1)C=CC=C2)COC1=CC(CN2CCCCC2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zolantidine dimaleate

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for Zolantidine dimaleate

The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for Zolantidine dimaleate

Certificate of Analysis / Product Datasheet
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References for Zolantidine dimaleate

References are publications that support the biological activity of the product.

Calcutt et al (1988) Zolantidine (SK&F 95282) is a potent selective brain penetrating histamine H2-receptor antagonist. Br.J.Pharmacol. 93 69 PMID: 2894879

Coruzzi et al (1994) Activity of the new histamine H2-receptor antagonist zolantidine at cardiac and gastric H2 receptors. Pharmacology 48 69 PMID: 7907797

Coruzzi et al (1996) Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity. Br.J.Pharmacol. 118 1813 PMID: 8842448

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Keywords: Zolantidine dimaleate, Zolantidine dimaleate supplier, Potent, centrally, active, H2, antagonists, Receptors, Histamine, histaminergic, GlaxoSmithKline, GSK, 1070, Tocris Bioscience

1 Citation for Zolantidine dimaleate

Citations are publications that use Tocris products. Selected citations for Zolantidine dimaleate include:

Porter et al (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315 711 PMID: 16040814

Do you know of a great paper that uses Zolantidine dimaleate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.