Zolantidine dimaleate

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Cat.No. 1070 - Zolantidine dimaleate | C22H27N3OS.2C4H4O4 | CAS No. 104076-39-3
Description: Potent, centrally active H2 antagonist
Chemical Name: N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine dimaleate
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

A potent, selective and brain penetrating H2 receptor antagonist.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 613.68
Formula C22H27N3OS.2C4H4O4
Storage Desiccate at +4°C
CAS Number 104076-39-3
PubChem ID 11957725
InChI Key IECBEVAUEBZJCF-SPIKMXEPSA-N
Smiles OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C(CNC1=NC2=C(S1)C=CC=C2)COC1=CC(CN2CCCCC2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Calcutt et al (1988) Zolantidine (SK&F 95282) is a potent selective brain penetrating histamine H2-receptor antagonist. Br.J.Pharmacol. 93 69 PMID: 2894879

Coruzzi et al (1994) Activity of the new histamine H2-receptor antagonist zolantidine at cardiac and gastric H2 receptors. Pharmacology 48 69 PMID: 7907797

Coruzzi et al (1996) Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity. Br.J.Pharmacol. 118 1813 PMID: 8842448


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Keywords: Zolantidine dimaleate, Zolantidine dimaleate supplier, Potent, centrally, active, H2, antagonists, Receptors, Histamine, histaminergic, GlaxoSmithKline, GSK, 1070, Tocris Bioscience

1 Citation for Zolantidine dimaleate

Citations are publications that use Tocris products. Selected citations for Zolantidine dimaleate include:

Porter et al (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315 711 PMID: 16040814


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Literature in this Area

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