Zolantidine dimaleate

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Cat.No. 1070 - Zolantidine dimaleate | C22H27N3OS.2C4H4O4 | CAS No. 104076-39-3
Description: Potent, centrally active H2 antagonist
Chemical Name: N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-2-benzothiazolamine dimaleate
Citations (1)

Biological Activity

A potent, selective and brain penetrating H2 receptor antagonist.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 613.68
Formula C22H27N3OS.2C4H4O4
Storage Desiccate at +4°C
CAS Number 104076-39-3
PubChem ID 11957725
Smiles OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C(CNC1=NC2=C(S1)C=CC=C2)COC1=CC(CN2CCCCC2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 61.37 100
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Calcutt et al (1988) Zolantidine (SK&F 95282) is a potent selective brain penetrating histamine H2-receptor antagonist. Br.J.Pharmacol. 93 69 PMID: 2894879

Coruzzi et al (1994) Activity of the new histamine H2-receptor antagonist zolantidine at cardiac and gastric H2 receptors. Pharmacology 48 69 PMID: 7907797

Coruzzi et al (1996) Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity. Br.J.Pharmacol. 118 1813 PMID: 8842448

If you know of a relevant reference for Zolantidine dimaleate, please let us know.

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Keywords: Zolantidine dimaleate, supplier, Potent, centrally, active, H2, antagonists, Receptors, Histamine, histaminergic, GlaxoSmithKline, GSK, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience

1 Citation for Zolantidine dimaleate

Citations are publications that use Tocris products. Selected citations for Zolantidine dimaleate include:

Porter et al (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315 711 PMID: 16040814

Do you know of a great paper that uses Zolantidine dimaleate from Tocris? If so please let us know.

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