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ZM 306416 hydrochloride
Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 370.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||27.01 mL||135.06 mL||270.12 mL|
|0.5 mM||5.4 mL||27.01 mL||54.02 mL|
|1 mM||2.7 mL||13.51 mL||27.01 mL|
|5 mM||0.54 mL||2.7 mL||5.4 mL|
References are publications that support the biological activity of the product.
Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369 PMID: 10639280
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5 Citations for ZM 306416 hydrochloride
Citations are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:
Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182 PMID: 25307081
Marino et al (2018) Regulation of breast cancer induced bone disease by cancer-specific IKKβ. Oncotarget 9 16134 PMID: 29662632
Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528 PMID: 25788671
Zhang et al (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Dis Model Mech 9 1383 PMID: 27562099
Lee et al (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun 5 5583 PMID: 25428693
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