ZM 306416 hydrochloride

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Cat.No. 2499 - ZM 306416 hydrochloride | C16H13N3O2FCl.HCl | CAS No. 196603-47-1
Description: Inhibitor of VEGF receptor tyrosine kinase
Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature
Pathways

Biological Activity

Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 370.21
Formula C16H13N3O2FCl.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 196603-47-1
PubChem ID 21701577
InChI Key SCUXIROMWPQVJO-UHFFFAOYSA-N
Smiles Cl.COC1=C(OC)C=C2C(NC3=CC=C(Cl)C=C3F)=NC=NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.7 10

Preparing Stock Solutions

The following data is based on the product molecular weight 370.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.51 mL 27.01 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369 PMID: 10639280


If you know of a relevant reference for ZM 306416 hydrochloride, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: inhibitors inhibits receptors tyrosine kinase VEGFR Vascular Endothelial Growth Factor Receptors KDR Flt RTKs ZM306416 hydrochloride AstraZeneca VEGFR

2 Citations for ZM 306416 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:

Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182 PMID: 25307081

Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528 PMID: 25788671


Do you know of a great paper that uses ZM 306416 hydrochloride from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for ZM 306416 hydrochloride

VEGF

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.

Protocols

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