ZM 306416 hydrochloride
Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 370.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.7 mL||13.51 mL||27.01 mL|
|5 mM||0.54 mL||2.7 mL||5.4 mL|
|10 mM||0.27 mL||1.35 mL||2.7 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369 PMID: 10639280
If you know of a relevant reference for ZM 306416 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: inhibitors inhibits receptors tyrosine kinase VEGFR Vascular Endothelial Growth Factor Receptors KDR Flt RTKs ZM306416 hydrochloride AstraZeneca VEGFR
2 Citations for ZM 306416 hydrochloride
Citations are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:
Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182 PMID: 25307081
Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528 PMID: 25788671
Do you know of a great paper that uses ZM 306416 hydrochloride from Tocris? If so please let us know.