ZLN 024 hydrochloride
Biological Activity
Allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.
Compound Libraries
ZLN 024 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 361.69 |
| Formula | C13H13BrN2OS.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| PubChem ID | 91654626 |
| InChI Key | MMQCYIMDROWWFE-UHFFFAOYSA-N |
| Smiles | BrC1=C(OCCSC2=NC=CC=N2)C=CC(C)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.17 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 361.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.82 mL | 27.65 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Li et al (2013) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 273 325 PMID: 24055643
Zhang et al (2013) Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8 e72092 PMID: 23977216
If you know of a relevant reference for ZLN 024 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ZLN 024 hydrochloride, ZLN 024 hydrochloride supplier, ZLN024, hydrochloride, allosteric, AMPK, activator, diabetes, mellitus, and, metabolic, syndrome, AMP, activated, protein, kinase, glucose, tolerance, Enzyme, Substrates, /, Activators, 5285, Tocris Bioscience
Citations for ZLN 024 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for ZLN 024 hydrochloride. Do you know of a great paper that uses ZLN 024 hydrochloride from Tocris? Please let us know.
Reviews for ZLN 024 hydrochloride
There are currently no reviews for this product. Be the first to review ZLN 024 hydrochloride and earn rewards!
Have you used ZLN 024 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Pathways for ZLN 024 hydrochloride
