ZLN 024 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 5285 - ZLN 024 hydrochloride | C13H13BrN2OS.HCl
Description: Allosteric AMPK activator
Chemical Name: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.

Compound Libraries

ZLN 024 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 361.69
Formula C13H13BrN2OS.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 91654626
InChI Key MMQCYIMDROWWFE-UHFFFAOYSA-N
Smiles BrC1=C(OCCSC2=NC=CC=N2)C=CC(C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.82 mL 27.65 mL
5 mM 0.55 mL 2.76 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2013) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 273 325 PMID: 24055643

Zhang et al (2013) Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8 e72092 PMID: 23977216


If you know of a relevant reference for ZLN 024 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all AMPK Activators

Keywords: ZLN 024 hydrochloride, supplier, ZLN024, hydrochloride, allosteric, AMPK, activator, diabetes, mellitus, and, metabolic, syndrome, AMP, activated, protein, kinase, glucose, tolerance, AMPK, Enzyme, Substrates, /, Activators, AMPK, Tocris Bioscience

Citations for ZLN 024 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for ZLN 024 hydrochloride. Do you know of a great paper that uses ZLN 024 hydrochloride from Tocris? If so please let us know.

Reviews for ZLN 024 hydrochloride

There are currently no reviews for this product. Be the first to review ZLN 024 hydrochloride and earn rewards!

Have you used ZLN 024 hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for ZLN 024 hydrochloride

AMPK

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.