Zardaverine

Pricing Availability   Qty
Description: PDE3/4 inhibitor
Chemical Name: 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (1)

Biological Activity for Zardaverine

Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively).

Technical Data for Zardaverine

M. Wt 268.22
Formula C12H10F2N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 101975-10-4
PubChem ID 5723
InChI Key HJMQDJPMQIHLPB-UHFFFAOYSA-N
Smiles COC1=C(OC(F)F)C=CC(=C1)C1=NNC(=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zardaverine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions for Zardaverine

The following data is based on the product molecular weight 268.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Zardaverine

Certificate of Analysis / Product Datasheet
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References for Zardaverine

References are publications that support the biological activity of the product.

Galvan and Schudt (1990) Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle. Naunyn Schmiedebergs Arch.Pharmacol. 342 221 PMID: 1700309

Kilian et al (1989) Is phosphodiesterase inhibition a relevant bronchospasmolytic principle? Agents Actions Suppl. 28 331 PMID: 2683636


If you know of a relevant reference for Zardaverine, please let us know.

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Keywords: Zardaverine, Zardaverine supplier, PDE3/4, inhibitors, inhibits, Phosphodiesterases, 1046, Tocris Bioscience

4 Citations for Zardaverine

Citations are publications that use Tocris products. Selected citations for Zardaverine include:

Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. Pain 183 279 PMID: 15531716

Gulyani et al (2009) Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp Neurol 215 236 PMID: 19013457

Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. J Neurosci 35 6639 PMID: 25926444

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333


Do you know of a great paper that uses Zardaverine from Tocris? Please let us know.

Reviews for Zardaverine

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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