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Submit ReviewZardaverine
Description: PDE3/4 inhibitor
Chemical Name: 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
Purity: ≥98% (HPLC)
Biological Activity for Zardaverine
Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively).
Technical Data for Zardaverine
| M. Wt | 268.22 |
| Formula | C12H10F2N2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 101975-10-4 |
| PubChem ID | 5723 |
| InChI Key | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
| Smiles | COC1=C(OC(F)F)C=CC(=C1)C1=NNC(=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Zardaverine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions for Zardaverine
The following data is based on the product molecular weight 268.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
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Product Datasheets for Zardaverine
References for Zardaverine
References are publications that support the biological activity of the product.
Galvan and Schudt (1990) Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle. Naunyn Schmiedebergs Arch.Pharmacol. 342 221 PMID: 1700309
Kilian et al (1989) Is phosphodiesterase inhibition a relevant bronchospasmolytic principle? Agents Actions Suppl. 28 331 PMID: 2683636
If you know of a relevant reference for Zardaverine, please let us know.
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Keywords: Zardaverine, Zardaverine supplier, PDE3/4, inhibitors, inhibits, Phosphodiesterases, 1046, Tocris Bioscience
4 Citations for Zardaverine
Citations are publications that use Tocris products. Selected citations for Zardaverine include:
Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. J Neurosci 35 6639 PMID: 25926444
Gulyani et al (2009) Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp Neurol 215 236 PMID: 19013457
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. Pain 183 279 PMID: 15531716
Do you know of a great paper that uses Zardaverine from Tocris? Please let us know.
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