Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM. Geometric isomer of (E)-FeCP-oxindole (Cat. No. 3882).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.65||5mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 329.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.04 mL||15.19 mL||30.38 mL|
|5 mM||0.61 mL||3.04 mL||6.08 mL|
|10 mM||0.3 mL||1.52 mL||3.04 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600 PMID: 21359402
If you know of a relevant reference for (Z)-FeCP-oxindole, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (Z)-FeCP-oxindole, supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, VEGFR, VEGFR, Tocris Bioscience
Citations for (Z)-FeCP-oxindole
Citations are publications that use Tocris products.
Currently there are no citations for (Z)-FeCP-oxindole. Do you know of a great paper that uses (Z)-FeCP-oxindole from Tocris? If so please let us know.