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Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.
Geometric Isomer also available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.65||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 329.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||60.76 mL||303.79 mL||607.59 mL|
|0.25 mM||12.15 mL||60.76 mL||121.52 mL|
|0.5 mM||6.08 mL||30.38 mL||60.76 mL|
|2.5 mM||1.22 mL||6.08 mL||12.15 mL|
References are publications that support the biological activity of the product.
Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600 PMID: 21359402
Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918
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Keywords: (Z)-FeCP-oxindole, (Z)-FeCP-oxindole supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, VEGFR, 3883, Tocris Bioscience
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