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Cat.No. 3883 - (Z)-FeCP-oxindole | C19H15FeNO | CAS No. 1137967-28-2
Description: Selective VEGFR-2 inhibitor
Chemical Name: (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one
Literature (3)
Pathways (1)

Biological Activity

Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.

Geometric Isomer also available.

Technical Data

M. Wt 329.17
Formula C19H15FeNO
Storage Store at +4°C
CAS Number 1137967-28-2
PubChem ID 90488891
Smiles [Fe++].[CH-]1C=CC=C1.O=C1NC2=CC=CC=C2\C1=C\C1=CC=C[CH-]1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.65 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 329.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 60.76 mL 303.79 mL 607.59 mL
0.25 mM 12.15 mL 60.76 mL 121.52 mL
0.5 mM 6.08 mL 30.38 mL 60.76 mL
2.5 mM 1.22 mL 6.08 mL 12.15 mL

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References are publications that support the biological activity of the product.

Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors Metallomics 3 600 PMID: 21359402

Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918

If you know of a relevant reference for (Z)-FeCP-oxindole, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

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Citations for (Z)-FeCP-oxindole

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for (Z)-FeCP-oxindole


VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.